CAJ | 학술논문

预测了兽用盐酸多西环素注射液稳定pH值。在广泛pH范围内，采用经典恒温法和单测点法对所研制的盐酸多西环素注射液进行化学稳定性研究，探讨pH值与稳定性之间的关系。结果表明，这两种方法预测的稳定 pH 值及稳定 pH 值范围基本一致，盐酸多西环素注射液最稳定pH值[（ pH） m]为4．0，与经典法比较，单侧点法工作量小，简单易行。
예측료수용염산다서배소주사액은정pH치。재엄범pH범위내，채용경전항온법화단측점법대소연제적염산다서배소주사액진행화학은정성연구，탐토pH치여은정성지간적관계。결과표명，저량충방법예측적은정 pH 치급은정 pH 치범위기본일치，염산다서배소주사액최은정pH치[（ pH） m]위4．0，여경전법비교，단측점법공작량소，간단역행。
The stable pH value of the veterinary doxycycline hydrochloride injection was predicted. The chemical stability of doxycycline hydrochloride injection was studied in the extensive pH range by classical isothermal kinetic method and single point kinetic method. The relationship between stability and pH value of the injection was investigated. The results showed that, the most stable pH value and stable pH range that predicted by the two methods were basically identical. The most stable pH value of doxycycline hydrochloride injection was 4.0. Single point kinetic method was simple and its workload was small compared with the classical kinetic method.