海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
16期
2398-2400
,共3页
肝细胞癌%甲胎蛋白%高尔基体蛋白73%ROC曲线
肝細胞癌%甲胎蛋白%高爾基體蛋白73%ROC麯線
간세포암%갑태단백%고이기체단백73%ROC곡선
Hepatocellular carcinoma%Alpha-fetoprotein%Golgi protein 73%ROC curve
目的：探讨甲胎蛋白(AFP)与高尔基体蛋白73(GP73)对肝癌早期诊断的价值。方法采用酶联免疫法(Enzyme linked immunosorbent assay，ELISA)对肝癌患者80例、肝硬化患者30例血清中AFP、GP73进行检测，30例健康体检者作为对照。结果①肝癌组、肝硬化组、正常对照组AFP平均浓度为64.5μg/L、50.1μg/L、21.9μg/L (肝癌组vs对照组P<0.01，肝硬化组vs对照组P<0.01，肝硬化组vs肝癌组P<0.01)，肝癌组、肝硬化组、正常对照组GP73平均浓度为268.4μg/L、192.3μg/L、49.8μg/L (P<0.01)。②AFP诊断肝癌的ROC曲线下面积为0.729，P=0.000，GP73诊断肝癌的ROC曲线下面积为0.892，P=0.000。AFP联合GP73对肝癌诊断的ROC曲线下面积为0.902。结论 GP73诊断肝癌的价值高于AFP，AFP+GP73联合检测不能提高诊断效率。
目的：探討甲胎蛋白(AFP)與高爾基體蛋白73(GP73)對肝癌早期診斷的價值。方法採用酶聯免疫法(Enzyme linked immunosorbent assay，ELISA)對肝癌患者80例、肝硬化患者30例血清中AFP、GP73進行檢測，30例健康體檢者作為對照。結果①肝癌組、肝硬化組、正常對照組AFP平均濃度為64.5μg/L、50.1μg/L、21.9μg/L (肝癌組vs對照組P<0.01，肝硬化組vs對照組P<0.01，肝硬化組vs肝癌組P<0.01)，肝癌組、肝硬化組、正常對照組GP73平均濃度為268.4μg/L、192.3μg/L、49.8μg/L (P<0.01)。②AFP診斷肝癌的ROC麯線下麵積為0.729，P=0.000，GP73診斷肝癌的ROC麯線下麵積為0.892，P=0.000。AFP聯閤GP73對肝癌診斷的ROC麯線下麵積為0.902。結論 GP73診斷肝癌的價值高于AFP，AFP+GP73聯閤檢測不能提高診斷效率。
목적：탐토갑태단백(AFP)여고이기체단백73(GP73)대간암조기진단적개치。방법채용매련면역법(Enzyme linked immunosorbent assay，ELISA)대간암환자80례、간경화환자30례혈청중AFP、GP73진행검측，30례건강체검자작위대조。결과①간암조、간경화조、정상대조조AFP평균농도위64.5μg/L、50.1μg/L、21.9μg/L (간암조vs대조조P<0.01，간경화조vs대조조P<0.01，간경화조vs간암조P<0.01)，간암조、간경화조、정상대조조GP73평균농도위268.4μg/L、192.3μg/L、49.8μg/L (P<0.01)。②AFP진단간암적ROC곡선하면적위0.729，P=0.000，GP73진단간암적ROC곡선하면적위0.892，P=0.000。AFP연합GP73대간암진단적ROC곡선하면적위0.902。결론 GP73진단간암적개치고우AFP，AFP+GP73연합검측불능제고진단효솔。
Objective To explore the value of alpha-fetoprotein (AFP) and Golgi protein 73 (GP73) in the early diagnosis of hepatocellular carcinoma. Methods AFP and GP73 were detected with enzyme-linked immunosor-bent assay (enzyme linked immunosorbent assay, ELISA) in 80 patients with hepatocellular carcinoma and 30 patients with hepatocirrhosis. 30 healthy subjects were selected as controls. Results ①The mean concentrations of AFP in hepatocellular carcinoma group, hepatocirrhosis group and control group was 64.5, 50.1, and 21.9 respectively, among which there were significantly differences (P<0.01). The concentrations of GP73 in hepatocellular carcinoma group, hepatocirrhosis group and control group was 268.4, 192.3 and 49.8 respectively, among which there were significantly differences (P<0.01).②The areas under ROC curves of AFP and GP73 were 0.729 and 0.892 respectively in diagno-sis of hepatocellular carcinoma. The area under ROC curve of AFP combined GP73 was 0.902 for diagnosis of hepato-cellular carcinoma. Conclusion Compared with AFP, GP73 is more sensitive and accurate in diagnosis of liver can-cer, and it is not necessary to test GP73 combined with AFP.
