CAJ | 학술논문

目的：探讨奥美沙坦酯治疗慢性心力衰竭的疗效及其对血清IL-23的影响。方法选取我院心内科2012年5月至2013年5月收治的200例慢性心力衰竭患者为研究对象，应用随机数字表法将其分为对照组和观察组各100例，对照组患者接受常规治疗，观察组患者则在上述治疗的基础上加用奥美沙坦酯，治疗10周，比较两组患者的临床疗效、血清IL-23、B型脑钠肽(BNP)、Ⅰ型前胶原氨基端肽(PINP)、Ⅲ型前胶原氨基端肽(PIIINP)、左室舒张末期内径(LVEDD)和左室射血分数(LVEF)情况。结果治疗10周后，观察组患者治疗总有效率达98.00%，高于对照组的92.00%，差异有统计学意义(P<0.05)。观察组患者血清IL-23、BNP、PINP、PIIINP也明显低于对照组患者，差异均有统计学意义(P<0.05)。观察组患者的LVEDD和LVEF明显优于对照组患者，差异也有统计学意义(P<0.05)。结论奥美沙坦酯治疗慢性心力衰竭患者临床疗效确切，能够有效的控制血清IL-23、BNP、PINP、PIIINP各项实验室指标，优化LVEDD和LVEF，值得临床上进一步推广应用。
목적：탐토오미사탄지치료만성심력쇠갈적료효급기대혈청IL-23적영향。방법선취아원심내과2012년5월지2013년5월수치적200례만성심력쇠갈환자위연구대상，응용수궤수자표법장기분위대조조화관찰조각100례，대조조환자접수상규치료，관찰조환자칙재상술치료적기출상가용오미사탄지，치료10주，비교량조환자적림상료효、혈청IL-23、B형뇌납태(BNP)、Ⅰ형전효원안기단태(PINP)、Ⅲ형전효원안기단태(PIIINP)、좌실서장말기내경(LVEDD)화좌실사혈분수(LVEF)정황。결과치료10주후，관찰조환자치료총유효솔체98.00%，고우대조조적92.00%，차이유통계학의의(P<0.05)。관찰조환자혈청IL-23、BNP、PINP、PIIINP야명현저우대조조환자，차이균유통계학의의(P<0.05)。관찰조환자적LVEDD화LVEF명현우우대조조환자，차이야유통계학의의(P<0.05)。결론오미사탄지치료만성심력쇠갈환자림상료효학절，능구유효적공제혈청IL-23、BNP、PINP、PIIINP각항실험실지표，우화LVEDD화LVEF，치득림상상진일보추엄응용。
Objective To investigate the curative effect of olmesartan medoxomil on the treatment of chronic heart failure and its impact on the serum IL-23. Methods Two hundred patients with chronic heart failure in the De-partment of Cardiology in our hospital from May 2012 to May 2013 were selected and divided into control group and observation group by random number table. The control group received routine treatment, while the observation group patients were treated by olmesartan medoxomil besides the routine treatment. The clinical curative effect, serum IL-23 level, B-type brain natriuretic peptide (BNP), procollagen Ⅰ N-terminal peptide (PINP), procollagen Ⅲ N-terminal peptide (PIIINP), left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) of the two groups were compared after 10 weeks treatment. Results After 10 weeks treatment, the total effective rate of the observation group was 98%, which was significantly higher than that of the control group (92%) with statistically sig-nificant difference, P<0.05. Serum IL-23, BNP, PINP, PIIINP levels of the observation group were significantly lower than those of the control group with statistically significant difference, P<0.05. The left ventricular end diastolic diame-ter and left ventricular ejection fraction of the observation group were significantly better than those of the control group, with statistically significant difference, P<0.05. Conclusion The curative effect of olmesartan medoxomil on the treatment of chronic heart failure is distinguish, which can effectively control laboratory indexes, such as the se-rum levels of IL-23, BNP, PINP, PIIINP, and optimize the left ventricular end diastolic diameter and left ventricular ejection fraction. Therefore, it is worthy of further application in clinical practice.