CAJ | 학술논문

目的：检测BM Ps/BM PR/Smads信号转导通路上的BM PR Ⅰa人脑胶质瘤组织中的表达，研究其与人脑胶质瘤发生、发展中的作用及其与临床病理分级的关系。方法分别应用RT-PCR技术和免疫组织化学SABC法检测20例正常脑组织和40例不同级别人脑胶质瘤组织中BMPR Ⅰa mRNA和蛋白质表达量，并分析其与患者的年龄、性别、病理分级的相关性。结果人脑胶质瘤组织BM PR Ⅰa mRNA和蛋白质表达量比正常脑组织显著降低，并以Ⅲ、Ⅳ期肿瘤组织中的表达显著低于Ⅰ、Ⅱ期；上述指标的变化与患者的年龄及性别无关。结论在人脑胶质瘤发生、发展过程中BM PR Ⅰa可能起到抑制作用，且与年龄和性别无关。
목적：검측BM Ps/BM PR/Smads신호전도통로상적BM PR Ⅰa인뇌효질류조직중적표체，연구기여인뇌효질류발생、발전중적작용급기여림상병리분급적관계。방법분별응용RT-PCR기술화면역조직화학SABC법검측20례정상뇌조직화40례불동급별인뇌효질류조직중BMPR Ⅰa mRNA화단백질표체량，병분석기여환자적년령、성별、병리분급적상관성。결과인뇌효질류조직BM PR Ⅰa mRNA화단백질표체량비정상뇌조직현저강저，병이Ⅲ、Ⅳ기종류조직중적표체현저저우Ⅰ、Ⅱ기；상술지표적변화여환자적년령급성별무관。결론재인뇌효질류발생、발전과정중BM PR Ⅰa가능기도억제작용，차여년령화성별무관。
Objective To detect the expressions of BMPR Ⅰa of BMPs/BMPR/Smads signaling transduction pathway in human brain glioma ,to research the role of its in tumorigenesis and progression of brain glioma and its correlation to clinical pathology . Methods The mRNA and protein expressions of BMPR Ⅰa was detected in 20 normal brain tissues and 40 samples with human glioma by RT-PCR and SABC immunohistochemical methods ,repectively ,and analyzed the correlation with the patient′s age ,gender and pathological grade .Results Compared with normal brain tissues ,BMPR Ⅰa mRNA and protein expressions in human glioma were reduced significantly ,especially in Ⅲ and Ⅳ stage tumor tissues .The difference was not related with the patient′s age and gender .Conclusion In progression of glioma ,BMPR Ⅰa may play a role in restraining ,and has nothing to do with age and sex .