CAJ | 학술논문

目的：探讨脂质饮食对Beagle犬体内左氧氟沙星（Lfox）药动学的影响。方法6只Beagle犬分别在空腹或进食脂质状态下灌服Lfox胶囊10 mg/kg ，2周后交叉给药；采用高效液相色谱法测定不同时间（48 h内）血药浓度，用3p97软件计算二者的药动学参数并进行比较。结果 Beagle犬空腹组和进食脂质组的药-时曲线均符合二室模型；空腹组和进食脂质组Lfox主要药动学参数t1/2β分别为（11．07±8．46）、（21．79±4．59）h ，tmax分别为（3．42±0．41）、（2．00±0．32）h ，Cmax分别为（2．71±0．60）、（2．52±0．38）μg/mL ，AUC0→ t分别为（36．51±8．66）、（37．19±8．21）μg · h-1· mL -1；除Ka、t1/2Ka 、CL（F）、tmax参数两组比较差异均有统计学意义（P＜0．01或＜0．05）外，其他参数比较差异均无统计学意义（P＞0．05）。结论脂质饮食可使Beagle犬体内Lfox的吸收加快，tmax提前到达，而t1/2β/h延长，排出减慢，有益于Lfox在体内的储留。
목적：탐토지질음식대Beagle견체내좌양불사성（Lfox）약동학적영향。방법6지Beagle견분별재공복혹진식지질상태하관복Lfox효낭10 mg/kg ，2주후교차급약；채용고효액상색보법측정불동시간（48 h내）혈약농도，용3p97연건계산이자적약동학삼수병진행비교。결과 Beagle견공복조화진식지질조적약-시곡선균부합이실모형；공복조화진식지질조Lfox주요약동학삼수t1/2β분별위（11．07±8．46）、（21．79±4．59）h ，tmax분별위（3．42±0．41）、（2．00±0．32）h ，Cmax분별위（2．71±0．60）、（2．52±0．38）μg/mL ，AUC0→ t분별위（36．51±8．66）、（37．19±8．21）μg · h-1· mL -1；제Ka、t1/2Ka 、CL（F）、tmax삼수량조비교차이균유통계학의의（P＜0．01혹＜0．05）외，기타삼수비교차이균무통계학의의（P＞0．05）。결론지질음식가사Beagle견체내Lfox적흡수가쾌，tmax제전도체，이t1/2β/h연장，배출감만，유익우Lfox재체내적저류。
Objective To study the effect of lipide diet on pharmacokinetics of levofloxacin (Lfox) in beagle dogs .Methods In randomized cross over experiment ,6 Beagle dogs were given Lfox 10 mg/kg at the condition of empty stomach or with lipide diet for 2 week .Plasma concentration of Lfox was determined by HPLC at different time (during 48 h) .The pharmacokinetic parameters were calculated by 3p97 software .Results The plasma concentration-time curves were two compartment modelat the condition of empty stomach or lipide diet .Main pharmacokinetic parameters were as follows :t1/2β:(11 .07 ± 8 .46)and(21 .79 ± 4 .59)h ;tmax :(3 .42 ± 0 .41) and(2 .00 ± 0 .32)h;Cmax :(2 .71 ± 0 .60)and(2 .52 ± 0 .38)μg/mL ;AUC0→ t :(36 .51 ± 8 .66) and(37 .19 ± 8 .21)μg · h-1 · mL -1 ,respectively .There were significant differences in pharmacokinetic parameters of tmax (P<0 .01)except for t1/2β、Cmax and AUC0→ t .Conclusion Lipide diet can quicken tmax ,has no effect on the absorption of Lfox .