CAJ | 학술논문

目的：探讨FOXM 1转录因子在宫颈癌组织中的表达水平及其临床意义。方法采用免疫组织化学染色法，检测38例宫颈癌、22例宫颈上皮内瘤样病变（CINⅠ～Ⅲ）和17例正常宫颈组织中FOXM 1和Ki-67的表达水平。结果 FOXM 1在正常宫颈、CIN和宫颈癌组织中的异常表达率分别为5．88％、63．6％和92．1％；FOXM1异常表达水平与宫颈癌患者的病理分化程度、临床分期、术后复发以及Ki-67表达水平均高度相关。结论 FOXM1可能与宫颈癌组织的异常增殖、恶性进展、分期和预后相关。
목적：탐토FOXM 1전록인자재궁경암조직중적표체수평급기림상의의。방법채용면역조직화학염색법，검측38례궁경암、22례궁경상피내류양병변（CINⅠ～Ⅲ）화17례정상궁경조직중FOXM 1화Ki-67적표체수평。결과 FOXM 1재정상궁경、CIN화궁경암조직중적이상표체솔분별위5．88％、63．6％화92．1％；FOXM1이상표체수평여궁경암환자적병리분화정도、림상분기、술후복발이급Ki-67표체수평균고도상관。결론 FOXM1가능여궁경암조직적이상증식、악성진전、분기화예후상관。
Objective To detect the expression of FOXM 1 transcription factor in cervical cancer tissues and to evaluate its clini-cal significance .Methods Immunohistochemical staining was employed to detect the expression of both FOXM 1 and Ki-67 in a va-riety of cervical tissues respectively from 38 patients with cervical cancer ,22 with cervical intraepithelial neoplasia (ranging from CINⅠ to CIN Ⅲ) and 17 with normal cervical epithelium .Results Abnormal expression rate of FOXM 1 was respectively 5 .88% , 63 .6% and 92 .1% in normal cervix ,CIN and cervical cancer ;Deregulated FOXM1 expression in cervical cancer tissues was signifi-cantly correlated with patients’ pathological differentiation ,clinical stage ,post-operational recurrence and Ki-67 expression level . Conclusion FOXM1 expression may be correlated with the deregulated proliferation ,malignant progression ,staging and prognosis in cervical cancer .