CAJ | 학술논문

目的：应用弥散张量成像（DTI）技术获取全脑白质各向异性（FA）值，研究首发儿童青少年精神分裂症全脑白质纤维是否受到损害，探讨早发精神分裂症的白质异常与精神分裂症的关联性。方法入组符合DSM-Ⅳ诊断标准的首发精神分裂症患者共19例（患者组），患者年龄均小于18岁，没有使用过任何抗精神病药物。同时选取19名年龄、性别相匹配的健康自愿者（对照组）。所有的患者和健康对照者都接受了DTI和结构相的磁共振成像（MRI）扫描。检测大脑各区域的FA值，分析患者组与健康对照组之间FA值的差异。结果患者组左额下回、左颞下回、左枕叶、右颞中回白质 FA值显著低于健康对照组（ P＜0．001）。结论首发儿童青少年精神分裂症患者脑区存在广泛的白质损伤，提示白质异常可能与早发精神分裂的发病相关。
목적：응용미산장량성상（DTI）기술획취전뇌백질각향이성（FA）치，연구수발인동청소년정신분렬증전뇌백질섬유시부수도손해，탐토조발정신분렬증적백질이상여정신분렬증적관련성。방법입조부합DSM-Ⅳ진단표준적수발정신분렬증환자공19례（환자조），환자년령균소우18세，몰유사용과임하항정신병약물。동시선취19명년령、성별상필배적건강자원자（대조조）。소유적환자화건강대조자도접수료DTI화결구상적자공진성상（MRI）소묘。검측대뇌각구역적FA치，분석환자조여건강대조조지간FA치적차이。결과환자조좌액하회、좌섭하회、좌침협、우섭중회백질 FA치현저저우건강대조조（ P＜0．001）。결론수발인동청소년정신분렬증환자뇌구존재엄범적백질손상，제시백질이상가능여조발정신분렬적발병상관。
Objective To investigated cerebral structural connectivity and its relationship to neuroleptic-na?ve individuals with first episode early-onset schizophrenia using diffusion tensor imaging (DTI) which could demonstrate the white matter integrity . Methods We recruited subjects with first episode DSM-Ⅳearly-onset schizophrenia who had never been exposed to antipsychotic medication(n=19) and sex ,age-matched healthy volunteers (n= 19) .All subjects received DTI and structural magnetic resonance imaging scans .Voxel-based analysis was performed to investigate brain regions fractional anisotropy (FA) values .Results Statistics revealed that schizophrenia patients showed significant FA reduction in left inferior frontal gyrus ,left temporal gyrus ,left occipital lobe and right middle temporal gyrus as compared to healthy subjects .Conclusion Deficits of white matter integrity in widespread brain regions of the first episode neuroleptic-na?ve early-onset schizophrenia patients .The presence of white matter abnormalities in the early-onset patients is suggestive of being related to the etilology of schizophrenia .