CAJ | 학술논문

目的：探讨甲磺酸双氢麦角毒碱治疗缺血性卒中所致头痛的临床疗效。方法将78例缺血性卒中所致头痛患者随机分为两组，治疗组42例，给予口服甲磺酸双氢麦角毒碱（2mg，每日3次）；对照组36例，给予口服安慰剂。1周为1疗程，可以多疗程治疗。通过头痛日记观察临床疗效。结果治疗组和对照组在性别、年龄、急性缺血性脑卒中试验（TOAST）分型、神经功能缺损评估（NIHSS）评分、头痛性质和部位等方面比较差异无统计学意义（P＞0．05）。治疗组头痛病程比对照组短（3．78±1．44vs．4．88±1．45，P＝0．002）。治疗组平均头痛程度在卒中起病第3天开始比对照组明显减轻（P＜0．05）。结论甲磺酸双氢麦角毒碱能缩短缺血性卒中所致头痛的病程和降低头痛程度，有助于提高患者生活质量。
목적：탐토갑광산쌍경맥각독감치료결혈성졸중소치두통적림상료효。방법장78례결혈성졸중소치두통환자수궤분위량조，치료조42례，급여구복갑광산쌍경맥각독감（2mg，매일3차）；대조조36례，급여구복안위제。1주위1료정，가이다료정치료。통과두통일기관찰림상료효。결과치료조화대조조재성별、년령、급성결혈성뇌졸중시험（TOAST）분형、신경공능결손평고（NIHSS）평분、두통성질화부위등방면비교차이무통계학의의（P＞0．05）。치료조두통병정비대조조단（3．78±1．44vs．4．88±1．45，P＝0．002）。치료조평균두통정도재졸중기병제3천개시비대조조명현감경（P＜0．05）。결론갑광산쌍경맥각독감능축단결혈성졸중소치두통적병정화강저두통정도，유조우제고환자생활질량。
Objective This clinical study was designed to explore the therapeutic efficacy of dihydroergotoxine for headache at-tributed to ischemic stroke .Methods Seventy eight patients fulfilling the diagnostic criteria of headache attributed to ischemic stroke were enrolled and randomly divided into two treatment group(n=42) and control group(n=36) who took dihydroergotoxine (2 mg twice daily) and placebo respectively .One week for a course of treatment ,had many courses of treatment .Efficacy was as-sessed using the patient′s diary .Results The gender ,age ,stroke aetiology ,admission NIHSS score ,quality and location of headache didn′t differ significantly between the two groups .Compared with the control group ,the duration of headache were shorter in treat-ment group(3 .78 ± 1 .44 vs .4 .88 ± 1 .45 ,P=0 .002) .The severity of headache were lower in treatment group since the third day post ischemic stroke(P<0 .05) .There were no significant side effects during treatment .Conclusion Dihydroergotoxine in treat-ment of headache attributed to ischemic stroke is beneficial to shorten the duration of headache as well as decrease the severity of headache ,and thereby improve the quality of life .