CAJ | 학술논문

目的：分析评价重庆市主城区肺结核耐药情况，为下一步耐药防治工作提出建议。方法对主城区2009年9月至2010年6月期间新登记的涂阳肺结核患者进行问卷调查，同时开展患者痰培养、药敏试验等相关实验室检测，对结果进行分析。结果主城区涂阳肺结核患者总耐药率、耐多药率分别为27．62％、10．50％，初治、复治患者耐多药率分别为6．99％、23．68％；181例肺结核患者耐药率顺序为异烟肼（H ）为19．34％、链霉素（S ）为18．23％、利福平（R ）为13．26％、乙胺丁醇（E ）为11．05％、氧氟沙星（Ofx）为6．08％、卡那霉素（Km）为2．21％；50例耐药患者中，共计有20种结核病耐药谱型；男性、既往接受过抗结核治疗、咳嗽咳痰大于等于2周在耐药和非耐药肺结核患者间差异有统计学意义（P＜0．05）。结论重庆市主城区肺结核耐药疫情形势严峻，应将耐药监测工作日常化，同时关注可能产生耐药的相关因素。
목적：분석평개중경시주성구폐결핵내약정황，위하일보내약방치공작제출건의。방법대주성구2009년9월지2010년6월기간신등기적도양폐결핵환자진행문권조사，동시개전환자담배양、약민시험등상관실험실검측，대결과진행분석。결과주성구도양폐결핵환자총내약솔、내다약솔분별위27．62％、10．50％，초치、복치환자내다약솔분별위6．99％、23．68％；181례폐결핵환자내약솔순서위이연정（H ）위19．34％、련매소（S ）위18．23％、리복평（R ）위13．26％、을알정순（E ）위11．05％、양불사성（Ofx）위6．08％、잡나매소（Km）위2．21％；50례내약환자중，공계유20충결핵병내약보형；남성、기왕접수과항결핵치료、해수해담대우등우2주재내약화비내약폐결핵환자간차이유통계학의의（P＜0．05）。결론중경시주성구폐결핵내약역정형세엄준，응장내약감측공작일상화，동시관주가능산생내약적상관인소。
Objective To analyse and evaluate the status of drug-resistant tuberculosis of urban area of Chongqing ,and to pro-vide advice for the work of drug-resistant tuberculosis .Methods The smear positive TB cases registered between September 2009 and June 2010 were administered to questionnaire survey .At the same time ,the relating testing ,such as the sputum culture testing and drug susceptibility testing ,etc were conducted ,then analysis .Results The drug resistance rate and multi-drug resistant rate of smear positive TB cases of urban area were 27 .62% and 10 .50% respectively .The multi-drug resistant rate of new cases and re-treatment cases were 27 .62% and 23 .68% .The sequence of the rates of resistance were as follows :isoniazid(19 .34% ) ,streptomy-cin(18 .23% ) ,rifampicin(13 .26% ) ,ethambutol(11 .05% ) ,ofloxacin(6 .085% ) ,kanamycin(2 .21% ) .There were 20 types of drug-resistant spectrum among the 50 drug-resistant TB cases .The difference of the male gender and TB treatment and cough more than 2 weeks between the drug-resistant cases and the non drug-resistant cases were statistically significant (P<0 .05) .Conclusion The epidemic situation of drug-resistant tuberculosis of urban area is severe ,and the work of resistance monitoring should be routine . The correlative resistance factor should be concerned .