CAJ | 학술논문

目的：探讨血肌酐水平升高对急性冠脉综合征患者预后的影响。方法以2000年6月至2013年6月住院治疗且病历资料完整的急性冠脉综合征患者645例为研究对象，将住院期间血清肌酐水平较入院时增加25％的患者纳入肌酐增高组，其他患者纳入肌酐未升高组。采用Logistic回归模型分析肌酐水平与患者预后的关系。结果645例患者中，33例纳入肌酐水平增高组，612例纳入肌酐水平未增高组。肌酐水平增高组患者院内全因病死率，以及心力衰竭、心源性休克发生率均高于肌酐水平未增高组（P＜0．05）。Logistic回归分析显示，肌酐水平增高是急性冠脉综合征患者预后不良的预测因素（比值比为15．02，95％置信区间为10．64～40．05，P＜0．05）。结论血清肌酐水平增高是急性冠脉综合征患者院内死亡及心血管不良事件的预测因素之一。
목적：탐토혈기항수평승고대급성관맥종합정환자예후적영향。방법이2000년6월지2013년6월주원치료차병력자료완정적급성관맥종합정환자645례위연구대상，장주원기간혈청기항수평교입원시증가25％적환자납입기항증고조，기타환자납입기항미승고조。채용Logistic회귀모형분석기항수평여환자예후적관계。결과645례환자중，33례납입기항수평증고조，612례납입기항수평미증고조。기항수평증고조환자원내전인병사솔，이급심력쇠갈、심원성휴극발생솔균고우기항수평미증고조（P＜0．05）。Logistic회귀분석현시，기항수평증고시급성관맥종합정환자예후불량적예측인소（비치비위15．02，95％치신구간위10．64～40．05，P＜0．05）。결론혈청기항수평증고시급성관맥종합정환자원내사망급심혈관불량사건적예측인소지일。
Objective To explore the association between serum creatinine level and the prognosis of patients with acute coronary syndrome(ACS) .Methods A total of 645 ACS patients ,treated during Jun .2000 and Jun .2013 , were enrolled in this study .Patients with creatinine level increased 25% compared between in-hospital level and that before treatment were divided into creatinine increased group ,and the other patients were divided into creatinine not-increased group .Logistic analysis was used to analyze the relationship serum creatinine level and the in-hospital ad-verse events in ACS patients .Results Among all of the 645 ACS patients ,33 cases were enrolled as creatinine in-creased group ,and 612 patients were enrolled as creatinine not-increased group .Compared with patients in creatinine not-increase group ,all cause mortality and incidence of heart failure and cardiogenic shock in creatinine increased group were higher(P<0 .05) .Logistic analysis revealed that increased creatinine level was a predictor of adverse e-vents in patients suffered from ACS (odds ratio of 15 .02 ,95% confidence interval of 10 .64-40 .05 ,P<0 .05) .Con-clusion Increased serum creatinine levels could be one predictor of adverse events in ACS patients .