CAJ | 학술논문

目的：探讨尼莫地平联合脑脊液置换治疗蛛网膜下腔出血（SAH）的疗效。方法将122例SAH患者分成观察组和对照组，每组各61例。对照组采用尼莫地平常规治疗，观察组患者在对照组基础上加以脑脊液置换治疗。结果观察组左大脑前动脉（ACA）、右ACA、左大脑中动脉（MCA）、右MCA收缩峰流速值均高于对照组（P＜0．05）；观察组脑膜刺激征缓解率优于对照组（P＜0．05）；观察组血管痉挛、梗阻性脑积液、再出血发生率低于对照组（P＜0．05）。结论采用尼莫地平联合脑脊液置换治疗SAH ，能及时清除蛛网膜下腔积血，改善脑部血液循环，降低不良反应发生率，提高患者生存质量。
목적：탐토니막지평연합뇌척액치환치료주망막하강출혈（SAH）적료효。방법장122례SAH환자분성관찰조화대조조，매조각61례。대조조채용니막지평상규치료，관찰조환자재대조조기출상가이뇌척액치환치료。결과관찰조좌대뇌전동맥（ACA）、우ACA、좌대뇌중동맥（MCA）、우MCA수축봉류속치균고우대조조（P＜0．05）；관찰조뇌막자격정완해솔우우대조조（P＜0．05）；관찰조혈관경련、경조성뇌적액、재출혈발생솔저우대조조（P＜0．05）。결론채용니막지평연합뇌척액치환치료SAH ，능급시청제주망막하강적혈，개선뇌부혈액순배，강저불량반응발생솔，제고환자생존질량。
Objective To investigate the clinical effect of nimodipine combined with cerebrospinal fluid (CSF) replacement in treatment of subarachnoid hemorrhage (SAH) .Methods A total of 122 patients with SAH were di-vided into control group (61 cases) receiving conventional nimodipine therapy ,and observation group (61 cases) re-ceiving nimodipine combined with CSF replacement .Results The systolic peak flow velocity of left and right anterior cerebral artery (ACA) ,and left and right middle cerebral artery (MCA) in observation group were significantly high-er than those of control group (P<0 .05) .The remission rate of meningeal stimulation response of observation group was significantly higher than control group (P<0 .05) .The incidence rates of vascular spasm ,hydrocephalus and re-bleeding in observation group were significantly lower than control group (P<0 .05) .Conclusion The treatment of nimodipine combined with CSF replacement could remove subarachnoid hematocele quickly ,improve the brain blood circulation ,reduce the incidence rate adverse effect ,and improve the quality of life of patients .