CAJ | 학술논문

目的：探讨人类免疫缺陷病毒（HIV）感染患者继发恶性肿瘤的危险因素。方法对2003年1月至2013年8月确诊的HIV感染患者临床资料进行回顾性分析。结果HIV感染合并恶性肿瘤患者以50岁以上的人群为主，恶性肿瘤类型以非霍杰金淋巴瘤（NHL）为主，占25．33％；其次是宫颈癌，占18．67％。HIV感染合并恶性肿瘤患者CD4＋T淋巴细胞计数、CD4＋/CD8＋比值和自然杀伤细胞计数明显低于单纯HIV感染患者（P＜0．05）。结论年龄和免疫功能缺陷均增加了HIV感染者继发恶性肿瘤的风险。
목적：탐토인류면역결함병독（HIV）감염환자계발악성종류적위험인소。방법대2003년1월지2013년8월학진적HIV감염환자림상자료진행회고성분석。결과HIV감염합병악성종류환자이50세이상적인군위주，악성종류류형이비곽걸금림파류（NHL）위주，점25．33％；기차시궁경암，점18．67％。HIV감염합병악성종류환자CD4＋T림파세포계수、CD4＋/CD8＋비치화자연살상세포계수명현저우단순HIV감염환자（P＜0．05）。결론년령화면역공능결함균증가료HIV감염자계발악성종류적풍험。
Objective To investigate the risk factors of human immunodeficiency virus (HIV) infection-related malignant tumor .Methods The clinical data of patients with HIV infection ,diagnosed during January 2003 and Au-gust 2013 ,were collected and analyzed .Results Most of patients combined with HIV infection and malignant tumor were more than 50 years old .The most common types of malignant tumor were non-Hodgkin′s lymphoma (NHL) , accounting for 25 .33% ,and cervical cancer ,accounting for 18 .67% .The CD4+ cell counts ,CD4+ /CD8+ ratio and natural killer cell counts in patients combined with HIV infection and caner were lower than patients only with HIV infection (P<0 .05) .Conclusion Age and immunodeficiency could increase the risk of HIV infection-related malig-nant tumor .