CAJ | 학술논문

目的：研究丙氨酰谷氨酰胺对脓毒症的辅助治疗效果。方法以2010年8月至2013年2月清远市人民医院重症医学科（IC U ）收治的120脓毒症患者为研究对象，将其随机分为实验组和对照组，对照组采用常规治疗，实验组在常规治疗的基础上静脉滴注丙氨酰谷氨酰胺，剂量为0．4g/（kg×d），每日最大剂量为20g。比较两组患者治疗期间的胰岛素使用剂量、血糖水平、院内感染发生率、IC U住院时间、总住院时间及6月生存率。结果实验组与对照组胰岛素使用剂量分别为（3．8±3．1）、（4．5±3．5）IU/h ，血糖水平分别为（8．9±2．0）、（10．8±3．1）mol/L ，院内感染发生率分别为1．2‰及3．0‰，组间比较差异有统计学意义（P＜0．05）。但ICU住院时间、总住院时间、6月生存率组间比较差异无统计学意义（P＞0．05）。结论对于脓毒症患者，每日静脉滴注丙氨酰谷氨酰胺，可能有助于控制血糖水平、改善胰岛素抵抗、降低院内感染发生风险，但对患者预后无显著改善效果。
목적：연구병안선곡안선알대농독증적보조치료효과。방법이2010년8월지2013년2월청원시인민의원중증의학과（IC U ）수치적120농독증환자위연구대상，장기수궤분위실험조화대조조，대조조채용상규치료，실험조재상규치료적기출상정맥적주병안선곡안선알，제량위0．4g/（kg×d），매일최대제량위20g。비교량조환자치료기간적이도소사용제량、혈당수평、원내감염발생솔、IC U주원시간、총주원시간급6월생존솔。결과실험조여대조조이도소사용제량분별위（3．8±3．1）、（4．5±3．5）IU/h ，혈당수평분별위（8．9±2．0）、（10．8±3．1）mol/L ，원내감염발생솔분별위1．2‰급3．0‰，조간비교차이유통계학의의（P＜0．05）。단ICU주원시간、총주원시간、6월생존솔조간비교차이무통계학의의（P＞0．05）。결론대우농독증환자，매일정맥적주병안선곡안선알，가능유조우공제혈당수평、개선이도소저항、강저원내감염발생풍험，단대환자예후무현저개선효과。
Objective To investigate the effects of alanyl glutamine for the treatment of sepsis .Methods Be-tween August 2010 and February 2013 ,120 sepsis patients ,treated in this hospital ,were randomly divided into con-trol group ,given routine treatment ,and experiment group ,given intravenous injection of alanyl glutamine ,with dosage of 0 .4 g/(kg × d) and upper volume of 20 g/d ,except routine treatment .Dosage of insulin treatment ,glucose level , incidence of hospital infection ,length of ICU stay ,total length of hospital stay and overall survival rate in 6 month was respectively compared between the groups .Results In experiment group and control group ,dosage of insulin treatment were (3 .8 ± 3 .1) and (4 .5 ± 3 .5)IU/h ,glucose levels were (8 .9 ± 2 .0) and (10 .8 ± 3 .1)mol/L ,incidence of hospital infection were 1 .2‰ and 3 .0‰ ,all of which were with statistical difference (P<0 .05) ,but length of ICU stay ,total length of hospital stay and overall survival rate in 6 month were not significantly different (P>0 .05) . Conclusion For patients with sepsis ,intravenous injection of alanyl glutamine could be helpful for controlling blood glucose level ,improving insulin resistance and reducing the risk of nosocomial infection .However ,treatment of alanyl glutamine might be not obvious efficient to improve the prognosis .