CAJ | 학술논문

目的：探讨M K-801对海洛因成瘾大鼠学习记忆功能的影响。方法将30只SD大鼠随机分成海洛因成瘾组、MK801组及对照组。采用Morris水迷宫实验中的定位航行实验以及空间探索实验评价各组大鼠学习记忆能力。结果定位航行实验中，各组大鼠逃避潜伏期和搜索距离均随训练进程延长而逐渐缩短；成瘾组大鼠搜索距离大于M K-801组和对照组（ P＜0．05）。空间搜索实验中，成瘾组大鼠安全岛所在象限搜索时间及安全岛所在象限游泳距离占总距离的百分比均小于对照组及M K-801组（ P＜0．05），但对照组与M K-801组比较差异无统计学意义（ P＞0．05）。结论海洛因成瘾可损伤大鼠学习记忆能力，M K-801可减轻海洛因造成的大鼠学习记忆功能损伤。
목적：탐토M K-801대해락인성은대서학습기억공능적영향。방법장30지SD대서수궤분성해락인성은조、MK801조급대조조。채용Morris수미궁실험중적정위항행실험이급공간탐색실험평개각조대서학습기억능력。결과정위항행실험중，각조대서도피잠복기화수색거리균수훈련진정연장이축점축단；성은조대서수색거리대우M K-801조화대조조（ P＜0．05）。공간수색실험중，성은조대서안전도소재상한수색시간급안전도소재상한유영거리점총거리적백분비균소우대조조급M K-801조（ P＜0．05），단대조조여M K-801조비교차이무통계학의의（ P＞0．05）。결론해락인성은가손상대서학습기억능력，M K-801가감경해락인조성적대서학습기억공능손상。
Objective To study the effect of MK-801 on learning and memory function of heroin-addictive rats .Methods Thirty SD rats were randomly assigned into heroin dependent group ,MK-801 group and control group .The ability of special learning and memory were tested by Morris water maze .Results The escape latency and the searching distance of heroin dependent group were significantly longer than control group and MK-801 group in place navigation test (P<0 .05) .The explore time and the distance of original platform area in proportion to the total distance of heroin dependent group were less than control group and MK-801 group in spatial probe test (P<0 .05) . Conclusion Heroin dependence could impair the ability of learning and memory of rats .MK-801 could reduce the im-pairment of learning and memory function in heroin dependent rats .