CAJ | 학술논문

背景：膝关节交叉韧带损伤后自愈能力较差，治疗上以移植物植入重建交叉韧带为主。 　　目的：总结膝关节前交叉韧带的功能、结构，力学特点，及其缺损后人工韧带重建研究的进展，为人工韧带的临床应用提供依据。 　　方法：作者应用计算机检索数据库，检索关键词“人工合成材料；膝交叉韧带，韧带修复，运动，韧带重建。选择的文献内容与材料学特点、生物相容性及其膝关节韧带损伤相关领域的文章，共引用25篇文献，重点讨论重建膝关节交叉韧带的性能，及其生物材料的种类。 　　结果与结论：前交叉韧带重建作为治疗前交叉韧带损伤的有效治疗手段，近年来发展快速。目前国内外修复前交叉韧带损伤可供选择的移植物有自体组织替代物、同种异体韧带、生物组织工程韧带以及人工韧带等。人工合成材料与组织工程韧带近几年研究较多，生物型人工韧带对膝关节韧带损伤的修复取得了很好的效果。分子生物学技术以及基因学和细胞学在韧带中的运用，为未来膝关节韧带损伤的康复及治疗提供新的研究方向。
배경：슬관절교차인대손상후자유능력교차，치료상이이식물식입중건교차인대위주。 　　목적：총결슬관절전교차인대적공능、결구，역학특점，급기결손후인공인대중건연구적진전，위인공인대적림상응용제공의거。 　　방법：작자응용계산궤검색수거고，검색관건사“인공합성재료；슬교차인대，인대수복，운동，인대중건。선택적문헌내용여재료학특점、생물상용성급기슬관절인대손상상관영역적문장，공인용25편문헌，중점토론중건슬관절교차인대적성능，급기생물재료적충류。 　　결과여결론：전교차인대중건작위치료전교차인대손상적유효치료수단，근년래발전쾌속。목전국내외수복전교차인대손상가공선택적이식물유자체조직체대물、동충이체인대、생물조직공정인대이급인공인대등。인공합성재료여조직공정인대근궤년연구교다，생물형인공인대대슬관절인대손상적수복취득료흔호적효과。분자생물학기술이급기인학화세포학재인대중적운용，위미래슬관절인대손상적강복급치료제공신적연구방향。
BACKGROUND:The cruciate ligament of the knee joint has a poor capacity of self-healing after injury, and the main treatment is grafting to reconstruct cruciate ligament. OBJECTIVE:To summarize the structure, function, and mechanical characteristics of anterior cruciate ligament of the knee joint, the present research of artificial ligament reconstruction fol owing damage, and to provide evidences for clinical application of artificial ligament. METHODS:An online computer-based retrieval was performed with the key words of“artificial y synthetic materials, knee joint cruciate ligament, exercise, ligament repair, ligament reconstruction”. Articles related to knee ligament treatment approach, materials science characteristics, biocompatibility and application were included. A total of 25 articles addressing the properties of biological materials applied in knee cruciate ligament reconstruction were screened. RESULTS AND CONCLUSION:As an effective treatment for anterior cruciate ligament injuries, technique of anterior cruciate ligament reconstruction has been developed in recent years. Implants for repairing anterior cruciate ligament injuries include autologous ligaments, ligament al ograft, artificial ligaments, and tissue engineered ligament. Artificial materials and tissue engineered ligaments are the hotspots in recent years. Biological artificial ligament is effective to treat the knee ligament injury. celland molecular biology techniques as wel as the use of gene therapy wil become a new direction in the treatment of knee ligament injury and rehabilitation.