CAJ | 학술논문

背景：鼠神经生长因子对神经损伤后的修复和再生有促进作用，但目前实验研究表明不同用药方式的作用尚有争议。 　　目的：评价鼠神经生长因子不同给药方式治疗周围神经损伤的临床疗效。 　　方法：52例周围神经损伤的患者随机分为2组，试验组27例局部注射鼠神经生长因子；对照组25例全身注射鼠神经生长因子，1次/d，一个疗程4周，比较两组患者神经功能的修复情况及疗效。 　　结果与结论：与对照组相比，试验组优良率85%(23例)，有效率93%(25例)；对照组的优良率72%(18例)，有效率84%(21例)，两组优良率与有效率相比试验组显著优于对照组(P<0.05)。试验组中13例出现注射部位一过性痛，其中1例患者口服镇痛药物缓解；对照组中12例患者出现注射部位一过性疼痛，未做处理。结果提示，鼠神经生长因子治疗周围神经损伤安全有效，局部注射疗效优于全身用药。
배경：서신경생장인자대신경손상후적수복화재생유촉진작용，단목전실험연구표명불동용약방식적작용상유쟁의。 　　목적：평개서신경생장인자불동급약방식치료주위신경손상적림상료효。 　　방법：52례주위신경손상적환자수궤분위2조，시험조27례국부주사서신경생장인자；대조조25례전신주사서신경생장인자，1차/d，일개료정4주，비교량조환자신경공능적수복정황급료효。 　　결과여결론：여대조조상비，시험조우량솔85%(23례)，유효솔93%(25례)；대조조적우량솔72%(18례)，유효솔84%(21례)，량조우량솔여유효솔상비시험조현저우우대조조(P<0.05)。시험조중13례출현주사부위일과성통，기중1례환자구복진통약물완해；대조조중12례환자출현주사부위일과성동통，미주처리。결과제시，서신경생장인자치료주위신경손상안전유효，국부주사료효우우전신용약。
BACKGROUND:Mouse nerve growth factor can promote the repair and regeneration of injured nerves, but current experimental research shows that the effects of different treatment methods are stil controversial. OBJECTIVE:To evaluate the effect of mouse nerve growth factor injection via different ways on the treatment of peripheral nerve injury. METHODS:Total y 52 patients with peripheral nerve injury were randomly assigned into two groups:experimental group (local injection of mouse nerve growth factor, n=27) and control group (systemic administration of mouse nerve growth factor, n=25). The treatment was performed once a day, and lasted for 4 weeks. Then, the clinical efficacy and recovery of neurological function were compared. RESULTS AND CONCLUSION:The good and effective rates were 85%(n=23) and 93%(n=25) in the experimental group, while 72%(n=18) and 84%(n=21) in the control group, respectively, which were significantly better in the experimental group than the control group (P<0.05). In the experimental group, 13 cases developed transient pain at injection site, including one case of remission undergoing oral analgesics;in the control group, 12 cases had transient pain at injection site, without any treatment. The results suggest that both local and total body injection of mouse nerve growth factor are safe and effective for treatment of peripheral nerve injury, but local injection is superior to systemic administration.