中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
33期
5341-5345
,共5页
蔡思清%颜丽笙%李毅中%庄华烽%蔡冬鹭
蔡思清%顏麗笙%李毅中%莊華烽%蔡鼕鷺
채사청%안려생%리의중%장화봉%채동로
组织构建%骨组织构建%椎体骨折评估%骨密度%骨质疏松%诊断%绝经后女性%双能X射线骨密度仪%骨折风险%脆性骨折
組織構建%骨組織構建%椎體骨摺評估%骨密度%骨質疏鬆%診斷%絕經後女性%雙能X射線骨密度儀%骨摺風險%脆性骨摺
조직구건%골조직구건%추체골절평고%골밀도%골질소송%진단%절경후녀성%쌍능X사선골밀도의%골절풍험%취성골절
bone density%osteoporosis%postmenopause%diagnosis
背景：临床上用于诊断骨质疏松症的通用指标：脆性骨折或骨密度 T ≤-2.5标准差，只要满足一个条件即可作出骨质疏松的诊断。在做骨密度检查时同时进行椎体骨折评估，可以避免单一因素的评判造成骨质疏松症的漏诊，有利于提高骨质疏松的诊断率。<br> 目的：评估骨密度结合椎体骨折对骨质疏松症临床诊断率的影响。<br> 方法：对217例年龄≥50岁的绝经后女性患者行髋部骨密度检测，同时进行椎体骨折评估，比较单纯依靠骨密度检查与骨密度结合椎体骨折评估对骨质疏松的诊断率的影响，同时探讨骨密度对椎体骨折率的影响。<br> 结果与结论：92例骨密度T ≤-2.5，达到骨质疏松诊断阈值，占42.4%；102例骨密度-1> T >-2.5，为低骨量，占47.0%；23例骨密度在正常范围，骨密度T>-1，占10.6%。158例无椎体骨折；59例(27.2%)椎体骨折，101个骨折椎。骨密度T>-2.5的患者椎体骨折率为21.6%，骨密度T ≤-2.5的患者椎体骨折率34.8%，两组骨折率比较差异有显著性意义(P <0.05)；骨密度结合椎体骨折评估的骨质疏松诊断率为54.8%，比单纯依靠骨密度检查，骨质疏松诊断率提高12.4%(P=0.01)。说明绝经后女性做骨密度检测的同时进行椎体骨折评估可以提高骨质疏松的诊断率。
揹景：臨床上用于診斷骨質疏鬆癥的通用指標：脆性骨摺或骨密度 T ≤-2.5標準差，隻要滿足一箇條件即可作齣骨質疏鬆的診斷。在做骨密度檢查時同時進行椎體骨摺評估，可以避免單一因素的評判造成骨質疏鬆癥的漏診，有利于提高骨質疏鬆的診斷率。<br> 目的：評估骨密度結閤椎體骨摺對骨質疏鬆癥臨床診斷率的影響。<br> 方法：對217例年齡≥50歲的絕經後女性患者行髖部骨密度檢測，同時進行椎體骨摺評估，比較單純依靠骨密度檢查與骨密度結閤椎體骨摺評估對骨質疏鬆的診斷率的影響，同時探討骨密度對椎體骨摺率的影響。<br> 結果與結論：92例骨密度T ≤-2.5，達到骨質疏鬆診斷閾值，佔42.4%；102例骨密度-1> T >-2.5，為低骨量，佔47.0%；23例骨密度在正常範圍，骨密度T>-1，佔10.6%。158例無椎體骨摺；59例(27.2%)椎體骨摺，101箇骨摺椎。骨密度T>-2.5的患者椎體骨摺率為21.6%，骨密度T ≤-2.5的患者椎體骨摺率34.8%，兩組骨摺率比較差異有顯著性意義(P <0.05)；骨密度結閤椎體骨摺評估的骨質疏鬆診斷率為54.8%，比單純依靠骨密度檢查，骨質疏鬆診斷率提高12.4%(P=0.01)。說明絕經後女性做骨密度檢測的同時進行椎體骨摺評估可以提高骨質疏鬆的診斷率。
배경：림상상용우진단골질소송증적통용지표：취성골절혹골밀도 T ≤-2.5표준차，지요만족일개조건즉가작출골질소송적진단。재주골밀도검사시동시진행추체골절평고，가이피면단일인소적평판조성골질소송증적루진，유리우제고골질소송적진단솔。<br> 목적：평고골밀도결합추체골절대골질소송증림상진단솔적영향。<br> 방법：대217례년령≥50세적절경후녀성환자행관부골밀도검측，동시진행추체골절평고，비교단순의고골밀도검사여골밀도결합추체골절평고대골질소송적진단솔적영향，동시탐토골밀도대추체골절솔적영향。<br> 결과여결론：92례골밀도T ≤-2.5，체도골질소송진단역치，점42.4%；102례골밀도-1> T >-2.5，위저골량，점47.0%；23례골밀도재정상범위，골밀도T>-1，점10.6%。158례무추체골절；59례(27.2%)추체골절，101개골절추。골밀도T>-2.5적환자추체골절솔위21.6%，골밀도T ≤-2.5적환자추체골절솔34.8%，량조골절솔비교차이유현저성의의(P <0.05)；골밀도결합추체골절평고적골질소송진단솔위54.8%，비단순의고골밀도검사，골질소송진단솔제고12.4%(P=0.01)。설명절경후녀성주골밀도검측적동시진행추체골절평고가이제고골질소송적진단솔。
BACKGROUND:The diagnosis of osteoporosis depends upon the bone mineral density T-score of ≤ -2.5 standard deviation or brittle fractures. Bone mineral density measurement combined with vertebral fracture assessment might prevent the missed diagnosis of osteoporosis due to bone mineral density evaluation alone, and improve the diagnosis rate of osteoporosis. <br> OBJECTIVE:To evaluate the effect of bone mineral density measurements combined with vertebral fracture assessment for the diagnosis of osteoporosis. <br> METHODS:Bone mineral density measurements of proximal femur and vertebral fracture assessment for lateral thoraco-lumbar images were consecutively done for 217 postmenopausal women who aged ≥ 50 years. The rate of osteoporosis diagnosed with bone mineral density T score was compared with that diagnosed with bone mineral density combined with vertebral fracture assessment. The effects of bone mineral density on the vertebral fracture were analyzed. <br> RESULTS AND CONCLUSION:92 (42.4%) patients had bone mineral density T score ≤ -2.5, which met the threshold for diagnosis of osteoporosis. 102 (47.0%) patients had osteopanic (-1>T>-2.5) and 23 (10.6%) had normal range of bone mineral density. 158 patients had no vertebral fractures and 59 (27.2%) patients had 101 vertebral fractures. The vertebral fracture rate was 21.6%in the patients with bone mineral density T> -2.5 and 34.8%in the patients with bone mineral density T ≤ -2.5, with significant differences (P<0.05). Bone mineral density in combination with vertebral fracture assessment for the diagnosis rate of osteoporosis was up to 54.8%, which was significantly higher than the rate diagnosed with only bone mineral density (12.4%;P=0.01). Bone mineral density measurement combined with vertebral fracture assessment improves the diagnosis of osteoporosis for postmenopausal women.
