CAJ | 학술논문

因为作用机制独特、抗肿瘤效果显著、抗肿瘤谱广等特点，铂类药物在恶性肿瘤的临床治疗中得到广泛应用。然而，已上市的铂类抗肿瘤药物在各类癌种的治疗过程中也存在着一定的局限性，暨在不同的实体瘤治疗中出现不同程度的毒副反应、耐药性或交叉耐药性等表现。目前，国内外关于铂类药物作用机制的报道较多，通过对已有研究的总结和梳理，不仅能够加强对这类特殊药物作用机制的认识，指导临床用药，而且能够为设计合成出疗效更佳、毒副作用更小、耐药程度更低的新型铂类抗肿瘤药物提供指导。本文就目前关于铂类药物抗肿瘤作用机制的国内外研究进展进行了综述。
인위작용궤제독특、항종류효과현저、항종류보엄등특점，박류약물재악성종류적림상치료중득도엄범응용。연이，이상시적박류항종류약물재각유암충적치료과정중야존재착일정적국한성，기재불동적실체류치료중출현불동정도적독부반응、내약성혹교차내약성등표현。목전，국내외관우박류약물작용궤제적보도교다，통과대이유연구적총결화소리，불부능구가강대저류특수약물작용궤제적인식，지도림상용약，이차능구위설계합성출료효경가、독부작용경소、내약정도경저적신형박류항종류약물제공지도。본문취목전관우박류약물항종류작용궤제적국내외연구진전진행료종술。
As one of the most important anticancer drugs with unique anticancer mechanism,high activity and broad anticancer spectrum,platinum-based drugs have been widely used in treatment of malignant tumors. However,the clinical application of platinum-based drugs has been greatly limited by its side effects,resistance or cross-resistance.Summarizing reported researches about anticancer mechanism of platinum-based drugs could deepen the understanding of the special anticancer mechanisms,provide directions in the clinical medication and give more information in designing and synthesizing novel platinum-based drugs with better efficiency,lower toxicity and less resistance.The research progress of platinum compounds for their anticancer mechanisms are therefore summarized in this paper.