CAJ | 학술논문

目的：总结分析恩替卡韦联合胸腺肽α1、糖皮质激素治疗重型乙型肝炎的临床效果。方法选择60例重型乙型肝炎患者为研究对象，随机分为观察组和对照组各30例，对照组患者给予常规治疗方案，观察组患者在常规治疗基础上给予恩替卡韦、胸腺肽α1、糖皮质激素治疗。结果观察组患者消化道症状缓解时间、黄疸缓解时间明显短于对照组（P ﹤0.05）；治疗后观察组 TBiL 水平明显低于对照组，而 PTA 水平明显高于对照组，差异具有统计学意义（P ﹤0.05）。结论恩替卡韦联合胸腺肽α1、糖皮质激素降阶梯治疗重型乙型肝炎的临床效果显著。
목적：총결분석은체잡위연합흉선태α1、당피질격소치료중형을형간염적림상효과。방법선택60례중형을형간염환자위연구대상，수궤분위관찰조화대조조각30례，대조조환자급여상규치료방안，관찰조환자재상규치료기출상급여은체잡위、흉선태α1、당피질격소치료。결과관찰조환자소화도증상완해시간、황달완해시간명현단우대조조（P ﹤0.05）；치료후관찰조 TBiL 수평명현저우대조조，이 PTA 수평명현고우대조조，차이구유통계학의의（P ﹤0.05）。결론은체잡위연합흉선태α1、당피질격소강계제치료중형을형간염적림상효과현저。
Objective:To investigate clinical efficacy of entecavir,thymosin α1 combined with glucocorticoids step-down therapy for severe hepatitis B. Methods:Sixty patients with severe hepatitis B in our hospital were divided into control group(30)treated with conventional therapy and observation group(30)treated with entecavir ,thymosin α1 combined with glucocorticoids. The clinical efficacy of two groups were compared. Results:Gastrointestinal symptoms remission time and jaundice remission time of observation group were significantly shorter than thsoe in the control group(P ﹤ 0. 05). TBiL level of the observation group was significantly lower than that of the control group and PTA level was significantly higher than that of the control group(P ﹤ 0. 05 ). Conclusion:Clinical efficacy of entecavir,thymosin α1 combined with glu-cocorticoids step-down therapy for severe hepatitis B is significant.