实用骨科杂志
實用骨科雜誌
실용골과잡지
JOURNAL OF PRACTICAL ORTHOPEDICS
2014年
8期
720-723
,共4页
环氧化酶抑制剂%多模式镇痛%颈后路单开门椎管扩大椎板成形术
環氧化酶抑製劑%多模式鎮痛%頸後路單開門椎管擴大椎闆成形術
배양화매억제제%다모식진통%경후로단개문추관확대추판성형술
cyclooxygenase inhibitors%multimodal analgesia%open door laminoplasty
目的:评价颈后路单开门椎管扩大椎板成形术后早期应用非选择性环氧化酶阻滞剂氟比洛芬酯注射液与选择性环氧化酶-2抑制剂注射用帕瑞昔布钠镇痛的有效性、安全性以及是否存在差异。方法前瞻性、随机、双盲、平行对照研究,根据纳入/排除标准,连续选取2010年3月至2013年3月在我科行颈后路单开门椎管扩大椎板成形术的患者60名,手术均采用全身麻醉,由同一组手术医师完成,两组病例均于切开皮肤前在手术切口周围注射“鸡尾酒”镇痛液(罗哌卡因注射液150 mg +肾上腺素(1:1000)0.5 mL,用生理盐水稀释为100 mL),帕瑞昔布钠组:术后6 h 开始给予帕瑞昔布钠40 mg,静注 q12 h,共6次。氟比洛芬酯组:术后6 h 开始给予氟比洛芬酯注射液100 mg,静注 q12 h,共6次。观察两组患者术后1~7 d 静息状态下和主动活动锻炼颈部最大屈伸位时的疼痛程度、颈部主动屈伸活动度、术后追加盐酸曲马多和盐酸哌替啶用量和发生不良反应例数、术后1个月复查时颈部屈伸活动度。结果术后1~7 d 在各观察点的静息状态和颈部最大主动屈伸位时的疼痛强度、颈部主动活动度、追加盐酸曲马多和盐酸哌替啶用量和发生不良反应例数及术后1个月颈部主动活动度的差异均无统计学意义(P ﹥0.05)。结论两种镇痛方案均效果良好,但不能认定颈后路单开门椎管扩大椎板成形术后短期镇痛中非选择性环氧化酶阻滞剂与选择性环氧化酶-2抑制剂之间存在差异。
目的:評價頸後路單開門椎管擴大椎闆成形術後早期應用非選擇性環氧化酶阻滯劑氟比洛芬酯註射液與選擇性環氧化酶-2抑製劑註射用帕瑞昔佈鈉鎮痛的有效性、安全性以及是否存在差異。方法前瞻性、隨機、雙盲、平行對照研究,根據納入/排除標準,連續選取2010年3月至2013年3月在我科行頸後路單開門椎管擴大椎闆成形術的患者60名,手術均採用全身痳醉,由同一組手術醫師完成,兩組病例均于切開皮膚前在手術切口週圍註射“鷄尾酒”鎮痛液(囉哌卡因註射液150 mg +腎上腺素(1:1000)0.5 mL,用生理鹽水稀釋為100 mL),帕瑞昔佈鈉組:術後6 h 開始給予帕瑞昔佈鈉40 mg,靜註 q12 h,共6次。氟比洛芬酯組:術後6 h 開始給予氟比洛芬酯註射液100 mg,靜註 q12 h,共6次。觀察兩組患者術後1~7 d 靜息狀態下和主動活動鍛煉頸部最大屈伸位時的疼痛程度、頸部主動屈伸活動度、術後追加鹽痠麯馬多和鹽痠哌替啶用量和髮生不良反應例數、術後1箇月複查時頸部屈伸活動度。結果術後1~7 d 在各觀察點的靜息狀態和頸部最大主動屈伸位時的疼痛彊度、頸部主動活動度、追加鹽痠麯馬多和鹽痠哌替啶用量和髮生不良反應例數及術後1箇月頸部主動活動度的差異均無統計學意義(P ﹥0.05)。結論兩種鎮痛方案均效果良好,但不能認定頸後路單開門椎管擴大椎闆成形術後短期鎮痛中非選擇性環氧化酶阻滯劑與選擇性環氧化酶-2抑製劑之間存在差異。
목적:평개경후로단개문추관확대추판성형술후조기응용비선택성배양화매조체제불비락분지주사액여선택성배양화매-2억제제주사용파서석포납진통적유효성、안전성이급시부존재차이。방법전첨성、수궤、쌍맹、평행대조연구,근거납입/배제표준,련속선취2010년3월지2013년3월재아과행경후로단개문추관확대추판성형술적환자60명,수술균채용전신마취,유동일조수술의사완성,량조병례균우절개피부전재수술절구주위주사“계미주”진통액(라고잡인주사액150 mg +신상선소(1:1000)0.5 mL,용생리염수희석위100 mL),파서석포납조:술후6 h 개시급여파서석포납40 mg,정주 q12 h,공6차。불비락분지조:술후6 h 개시급여불비락분지주사액100 mg,정주 q12 h,공6차。관찰량조환자술후1~7 d 정식상태하화주동활동단련경부최대굴신위시적동통정도、경부주동굴신활동도、술후추가염산곡마다화염산고체정용량화발생불량반응례수、술후1개월복사시경부굴신활동도。결과술후1~7 d 재각관찰점적정식상태화경부최대주동굴신위시적동통강도、경부주동활동도、추가염산곡마다화염산고체정용량화발생불량반응례수급술후1개월경부주동활동도적차이균무통계학의의(P ﹥0.05)。결론량충진통방안균효과량호,단불능인정경후로단개문추관확대추판성형술후단기진통중비선택성배양화매조체제여선택성배양화매-2억제제지간존재차이。
Objective To evaluate the pain relief effect of parecoxib sodium(selective cyclooxygenase-2 inhibitor)versus flurbiprofen axetil(non-selective cyclooxygenase inhibitor)used after open door laminoplasty in early short-term fuctional re-covery. Methods This is a prospective,randomized,double-blind,parallel and controlled study. According to inclusion/ exclu-sion criteria,60 patients undergoing open door laminoplasty were randomly assigned to one of the 2 groups from March,2010 to March,2013. All the operations were performed by the same group of surgeons under general anesthesia. Before the open door laminoplasty operation incision“cocktail anagesia injection”was given to every patient,which contained 150 mg ropivacaine, 0. 5 mL epinephrine(1 : 1 000). The parecoxib sodium group received parecoxib sodium(40 mg,every 12 hours)after six hours of surgery,while the flurbiprofen axetil group received flurbiprofen axetil(100 mg,every 12 hours)after six hours of sur-gery,the pain score(visual analog scale,VAS)at rest and during activity,active range of motion of the cervical from the first to the seventh postoperative day,active range of motion of the cervical on postoperative day 30,the dose of tramadol hydrochloride and pethidine hydrochloride used postoperatively and adverse reaction happened postoperatively. Results There were no sig-nificant differences in such outcome measures as VAS scores at rest and during activity,active range of motion of the cervical from the first to the seventh postoperative day,active range of motion of the cervical on postoperative day 30,the dose of tram-adol hydrochloride and pethidine hydrochloride used postoperatively and adverse reaction. Conclusion Preoperative analgesia by using selective cyclooxygenase-2 inhibitor and non-selective cyclooxygenase inhibitor are effective for postoperative pain management after open door laminoplasty. This study has not revealed that there is better pain relief effect of parecoxib sodium than flurbiprofen axetil after open door laminoplasty in early short-term fuctional recovery.