医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2014年
16期
2123-2125,2128
,共4页
梅振海%严家来%张大彩
梅振海%嚴傢來%張大綵
매진해%엄가래%장대채
肺炎克雷伯菌%超广谱β-内酰胺酶%耐药性%监测分析
肺炎剋雷伯菌%超廣譜β-內酰胺酶%耐藥性%鑑測分析
폐염극뢰백균%초엄보β-내선알매%내약성%감측분석
Pneumoniae%ESBLs%Drug resistance%Monitoring analysis
目的：了解本院近3年来肺炎克雷伯菌及其产超广谱β-内酰胺酶（ESBLs）菌株的分离率、耐药性及其发展趋势，为临床治疗提供依据。方法：对本院自2011年1月-2013年12月从临床标本分离的肺炎克雷伯菌及其产 ES-BLs菌株的分离率和药敏结果进行统计分析。结果：共检出肺炎克雷伯菌152株，其中产ESBLs有56株。肺炎克雷伯菌的检出率近3年无显著变化，但是产ESBLs菌株的检出率从2011年的23．4％上升到2013年的50.0％。药敏结果显示，产ESBLs菌株耐药率逐年增高，产ESBLs菌株的耐药率明显高于非产ESBLs菌株。结论：近3年来本地区产ESBLs肺炎克雷伯菌的检出率呈上升趋势，并呈现明显的多药耐药性，产ESBLs肺炎克雷伯菌的增加是导致肺炎克雷伯菌耐药率总体呈上升趋势的主要原因，也是导致其多重耐药的主要原因，医务人员应重视该菌引起的各类感染，减少医院感染的发生。
目的：瞭解本院近3年來肺炎剋雷伯菌及其產超廣譜β-內酰胺酶（ESBLs）菌株的分離率、耐藥性及其髮展趨勢，為臨床治療提供依據。方法：對本院自2011年1月-2013年12月從臨床標本分離的肺炎剋雷伯菌及其產 ES-BLs菌株的分離率和藥敏結果進行統計分析。結果：共檢齣肺炎剋雷伯菌152株，其中產ESBLs有56株。肺炎剋雷伯菌的檢齣率近3年無顯著變化，但是產ESBLs菌株的檢齣率從2011年的23．4％上升到2013年的50.0％。藥敏結果顯示，產ESBLs菌株耐藥率逐年增高，產ESBLs菌株的耐藥率明顯高于非產ESBLs菌株。結論：近3年來本地區產ESBLs肺炎剋雷伯菌的檢齣率呈上升趨勢，併呈現明顯的多藥耐藥性，產ESBLs肺炎剋雷伯菌的增加是導緻肺炎剋雷伯菌耐藥率總體呈上升趨勢的主要原因，也是導緻其多重耐藥的主要原因，醫務人員應重視該菌引起的各類感染，減少醫院感染的髮生。
목적：료해본원근3년래폐염극뢰백균급기산초엄보β-내선알매（ESBLs）균주적분리솔、내약성급기발전추세，위림상치료제공의거。방법：대본원자2011년1월-2013년12월종림상표본분리적폐염극뢰백균급기산 ES-BLs균주적분리솔화약민결과진행통계분석。결과：공검출폐염극뢰백균152주，기중산ESBLs유56주。폐염극뢰백균적검출솔근3년무현저변화，단시산ESBLs균주적검출솔종2011년적23．4％상승도2013년적50.0％。약민결과현시，산ESBLs균주내약솔축년증고，산ESBLs균주적내약솔명현고우비산ESBLs균주。결론：근3년래본지구산ESBLs폐염극뢰백균적검출솔정상승추세，병정현명현적다약내약성，산ESBLs폐염극뢰백균적증가시도치폐염극뢰백균내약솔총체정상승추세적주요원인，야시도치기다중내약적주요원인，의무인원응중시해균인기적각류감염，감소의원감염적발생。
Objective :To investigate the incidence and the statues of drug resistance of Klebsiella pneumoniae (K . pneumoniae) and K .pneumoniae producting extended spectrum beta-lactamases (ESBLs) and thereafter provide a basis for treatment in clinical practice .Methods :ESBLs were detected by sensitive tests with static methods in K .pnetumoni-ae which were isolated from January 2011 to December 2013 in the hospital .Results:There were 56 strains with ESBLs among 152 strains of K .pneumoniae .There were no significant differences between the incidence of Klebsiella pneu-moniae in recent three years .Meanwhile the rates of the producing ones with ESBLs were dramatically improved from 23 .4% in 2011 to 50.0% in 2013 .The result of sensitive tests confirmed that the drug resistance of ESBLs producing has a tendency of increasing every year ,and the rates of the producing ones with ESBLs were significantly higher than those of ESBLs non-producing strains .Conclusion:In view of increasing rate of ESBLs-producing Klebsiella pnetumoni-ae with multi-drug resistance in recent three years ,which as a result of the emergence of producing ones with ESBLs ,it is necessay to detect and supervise ESBLs in time for reducing the occurrence and spread of the bacteria stains with ES-BLs .
