CAJ | 학술논문

目的：应用Meta分析的方法，探讨高尿酸血症（Hyperuricemia ，HUA）与脑梗死的相关性。方法：检索关于中国大陆地区高尿酸血症与脑梗死发病关系的病例对照研究，用Stata/SE软件进行分析，计算合并的比值比（OR）及95％可信区间（CI），并对结果进行发表偏倚分析。结果：共纳入11篇文献，包括病例数1302例，对照数1151例。异质性检验：Q＝7．16，P＝0．71，I2＝0．0％，提示各研究间无明显异质性。用固定效应模型分析，合并OR的点估计和95％的可信区间为：4．74（3．80，5．90）。以Egger法进行发表性偏倚检验，得出 P＝0．093，漏斗图无明显不对称，表明研究无明显发表性偏倚。结论：HUA可增加脑梗死的发病几率，是脑梗死发病的危险因素。
목적：응용Meta분석적방법，탐토고뇨산혈증（Hyperuricemia ，HUA）여뇌경사적상관성。방법：검색관우중국대륙지구고뇨산혈증여뇌경사발병관계적병례대조연구，용Stata/SE연건진행분석，계산합병적비치비（OR）급95％가신구간（CI），병대결과진행발표편의분석。결과：공납입11편문헌，포괄병례수1302례，대조수1151례。이질성검험：Q＝7．16，P＝0．71，I2＝0．0％，제시각연구간무명현이질성。용고정효응모형분석，합병OR적점고계화95％적가신구간위：4．74（3．80，5．90）。이Egger법진행발표성편의검험，득출 P＝0．093，루두도무명현불대칭，표명연구무명현발표성편의。결론：HUA가증가뇌경사적발병궤솔，시뇌경사발병적위험인소。
Objective :To explore the relationship between Hyperuricemia(HUA) and cerebral infarction by Meta anal-ysis .Methods:Papers of case-control study concerning the relationship between Hyperuricemia and cerebral infarction in Chinese mainland were collected by computer .Stata/SE was applied to deal with the date and calculated with the odds ratio (OR) and 95% confidence interval (CI) .Finally ,possible publication bias was tested and a sensitivity analysis was conducted .Results:11 prospective studies meeting the criterion were included in this article .Heterogeneity across stud-ies was determined :Q= 7 .16 ,P=0 .71 ,I2 = 0 .0% .The results showed that there was no obvious heterogeneity be-tween studies .The meta analysis for all studies found a pooled OR of 4 .74(3 .80 ,5 .90)with a fixed-effect model .Pub-lication bias tested by the Egger’s test showed P=0 .093 .In addition ,funnel figure had no obvious asymmetry ,which showed no significant publication bias was found .Conclusion:HUA is a risk factor of cerebral infarction which can in-crease the risk of cerebral infarction .