CAJ | 학술논문

目的：探讨血清降钙素原（PC T ）检测对血流感染的诊断价值。方法回顾性分析2013年2～11月同时进行血培养和PC T检测的患者356例临床资料，以血培养检测结果将患者分为非血流感染组和血流感染组，比较两组间及革兰阴性菌感染组与革兰阳性菌感染组间血清PC T浓度的差异。结果非血流感染组、血流感染组血清PCT浓度分别为0．21（0．06～1．05）、4．36（0．78～15．60）ng/mL ，组间比较差异有统计学意义（P＜0．05）。革兰阴性菌与革兰阳性菌感染组血清PCT浓度分别为5．60（1．23～19．90）、2．04（0．59～9．05）ng/mL ，组间比较差异有统计学意义（ P＝0．041）。以0．50 ng/m L为临界值，PC T对血流感染的诊断灵敏度、特异度、阳性预测值和阴性预测值分别为83．1％、64．1％、41．3％、92．6％。结论 PC T定量检测用于血流感染的快速辅助诊断，也有利于血流感染病原菌类型的初步判断，能够为早期抗感染治疗方案的制订提供依据。
목적：탐토혈청강개소원（PC T ）검측대혈류감염적진단개치。방법회고성분석2013년2～11월동시진행혈배양화PC T검측적환자356례림상자료，이혈배양검측결과장환자분위비혈류감염조화혈류감염조，비교량조간급혁란음성균감염조여혁란양성균감염조간혈청PC T농도적차이。결과비혈류감염조、혈류감염조혈청PCT농도분별위0．21（0．06～1．05）、4．36（0．78～15．60）ng/mL ，조간비교차이유통계학의의（P＜0．05）。혁란음성균여혁란양성균감염조혈청PCT농도분별위5．60（1．23～19．90）、2．04（0．59～9．05）ng/mL ，조간비교차이유통계학의의（ P＝0．041）。이0．50 ng/m L위림계치，PC T대혈류감염적진단령민도、특이도、양성예측치화음성예측치분별위83．1％、64．1％、41．3％、92．6％。결론 PC T정량검측용우혈류감염적쾌속보조진단，야유리우혈류감염병원균류형적초보판단，능구위조기항감염치료방안적제정제공의거。
Objective To explore the diagnostic value of procalcitonin (PCT ) in bloodstream infection .Methods During Feb .2013 and Nov .2013 ,a total of 356 cases ,undertaking PCT and blood culture detection were divided in-to non-bloodstream infection group and bloodstream infection group ,according to results of blood culture .Mean-while ,cases in bloodstream infection group were divided into Gram-positive (G+ ) infection group and Gram-negative (G-) infection group .The differences of PCT between each group were analyzed .Results Levels of PCT in non-bloodstream infection group and bloodstream infection group were 0 .21(0 .06 -1 .05) and 4 .36(0 .78 -15 .60)ng/mL ,with statistical difference (P<0 .05) .Levels of PCT in G+ infection group and G - infection group were 2 .04 (0 .59-9 .05)and 5 .60(1 .23 -19 .90)ng/mL ,with statistical difference (P<0 .05) .When 0 .50 ng/mL was set as cut-off value of PCT for the diagnosis of bloodstream infection ,the sensitivity ,specificity ,positive and negative pre-dictive value were 83 .1% ,64 .1% ,41 .3% and 92 .6% .Conclusion Quantitative detection of PCT could be used for the rapid diagnosis of bloodstream infection ,which might be useful to identify the types of pathogenic bacteria and to provide evidence for making plans of early anti-infection therapy .