中医药学报
中醫藥學報
중의약학보
ACTA CHINESE MEDICINE AND PHARMACOLOGY
2014年
4期
150-152
,共3页
杨和强%何跃%郭晓静%余巧
楊和彊%何躍%郭曉靜%餘巧
양화강%하약%곽효정%여교
放疗%头颈部肿瘤%中药
放療%頭頸部腫瘤%中藥
방료%두경부종류%중약
Radiotherapy%Head and neck tumor%Chinese medicine
目的：探究中西医结合治疗头颈部肿瘤患者的临床疗效和不良反应，为改善头颈部肿瘤患者的临床症状提供试验依据。方法：82例患者随机分为对照组和观察组，每组各41例。两组都接受放射治疗，观察组在对照组基础上接受中药治疗。比较两组患者的疗效、卡氏评分和不良反应。结果：对照组的总有效率为73．2％，疾病控制率为82．9％。观察组的总有效率为78％，疾病控制率92．7％。观察组的总有效率、疾病控制率与对照组相比，差异不明显（χ2＝1．82，0．27，P ＞0．05）。对照组卡氏评分有效率为75．6％，观察组卡氏评分有效率为92．7％；观察组的有效率高于对照组，差异明显，具有统计学意义（χ2＝4．48，P ＜0．05）；对照和观察组白细胞下降的发生率差异明显，具有统计学意义（χ2＝4．9，P ＜0．05）；对照组和观察组口干的发生率差异明显，具有统计学意义（χ2＝4．32，P ＜0．05）。结论：采用滋阴解毒中药辅助放疗在疾病控制率上和总有效率上与单用放疗无明显差异，但是可以提高患者的生存质量，改善不良反应。该方案临床使用，具有一定的可行性。
目的：探究中西醫結閤治療頭頸部腫瘤患者的臨床療效和不良反應，為改善頭頸部腫瘤患者的臨床癥狀提供試驗依據。方法：82例患者隨機分為對照組和觀察組，每組各41例。兩組都接受放射治療，觀察組在對照組基礎上接受中藥治療。比較兩組患者的療效、卡氏評分和不良反應。結果：對照組的總有效率為73．2％，疾病控製率為82．9％。觀察組的總有效率為78％，疾病控製率92．7％。觀察組的總有效率、疾病控製率與對照組相比，差異不明顯（χ2＝1．82，0．27，P ＞0．05）。對照組卡氏評分有效率為75．6％，觀察組卡氏評分有效率為92．7％；觀察組的有效率高于對照組，差異明顯，具有統計學意義（χ2＝4．48，P ＜0．05）；對照和觀察組白細胞下降的髮生率差異明顯，具有統計學意義（χ2＝4．9，P ＜0．05）；對照組和觀察組口榦的髮生率差異明顯，具有統計學意義（χ2＝4．32，P ＜0．05）。結論：採用滋陰解毒中藥輔助放療在疾病控製率上和總有效率上與單用放療無明顯差異，但是可以提高患者的生存質量，改善不良反應。該方案臨床使用，具有一定的可行性。
목적：탐구중서의결합치료두경부종류환자적림상료효화불량반응，위개선두경부종류환자적림상증상제공시험의거。방법：82례환자수궤분위대조조화관찰조，매조각41례。량조도접수방사치료，관찰조재대조조기출상접수중약치료。비교량조환자적료효、잡씨평분화불량반응。결과：대조조적총유효솔위73．2％，질병공제솔위82．9％。관찰조적총유효솔위78％，질병공제솔92．7％。관찰조적총유효솔、질병공제솔여대조조상비，차이불명현（χ2＝1．82，0．27，P ＞0．05）。대조조잡씨평분유효솔위75．6％，관찰조잡씨평분유효솔위92．7％；관찰조적유효솔고우대조조，차이명현，구유통계학의의（χ2＝4．48，P ＜0．05）；대조화관찰조백세포하강적발생솔차이명현，구유통계학의의（χ2＝4．9，P ＜0．05）；대조조화관찰조구간적발생솔차이명현，구유통계학의의（χ2＝4．32，P ＜0．05）。결론：채용자음해독중약보조방료재질병공제솔상화총유효솔상여단용방료무명현차이，단시가이제고환자적생존질량，개선불량반응。해방안림상사용，구유일정적가행성。
Objective: To explore clinical efficacy and adverse reaction of integrative medicine in the treatment of 82 pa-tients with head and neck cancer.By doing the study, we provided clinical evidence for the therapy of patients head and neck cancer.Methods: 82 patients were divided into two groups randomly .There were 41 patients in each group.Two groups were treated with radiation therapy .The observation group was given Chinese medicine on the basis of therapy in control group.The efficacy of patients, Karnofsky score and adverse reactions in two groups were compared .Results:The total effective rate of the control group was 73.2%.Disease control rate in control group was 82.9%.The total ef-fective rate of observation group was 78%.Disease control rate in observation group was 92.7%.The total detoxification combined with rate and disease control rate in two groups had no significant difference (χ2 =1.82,0.27,P >0.05). The effective rate of Karnofsky score in control group was 75.6%.Effective rate of Karnofsky score in observation group was 92.7%.The effective rate of Karnofsky score was higher than that of observation group .The results had a signifi-cant difference (χ2 =4.48,P <0.05).The incidence rate in control group and observation group had a significant difference (x2 =4.9,P <0.05);the incidence rate of dry mouth in control group and observation group had a significant difference(χ2 =4.32,P <0.05).Conclusion:Chinese medicine of nourishing Yin and detoxification combined with ra -diotherapy in the treatment of cancer and disease control rate had no difference with the single radiotherapy , but that chi-nese medicine can improve the quality of life of patients and reduce adverse reactions .The program is feasible and de-served to be applied in the clinical therapy .
