中医药学报
中醫藥學報
중의약학보
ACTA CHINESE MEDICINE AND PHARMACOLOGY
2014年
4期
142-145
,共4页
溃疡性结肠炎%肠炎宁胶囊%美沙拉嗪%联合治疗
潰瘍性結腸炎%腸炎寧膠囊%美沙拉嗪%聯閤治療
궤양성결장염%장염저효낭%미사랍진%연합치료
Ulcerative colitis%Changyanning capsule%Mesalazine%Combined treatment
目的：探讨肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法：选择2010年1月～2013年9月在我院住院治疗的溃疡性结肠炎患者89例为研究对象，按就诊顺序随机分为试验组和对照组，试验组45例给予肠炎宁胶囊联合美沙拉嗪治疗，对照组44例单用美沙拉嗪治疗，对两组患者的血清 IL -1、IL -8、TNF -α、Fib、MPV 及临床治疗效果进行比较。结果：经过30天的治疗，两组患者血清 IL -1、IL -8、TNF -α、Fib、MPV 均显著下降（均 P ＜0．05）。试验组治疗后的 IL -1、IL -8、TNF -α、Fib、MPV 均不同程度低于对照组，差异均有统计学意义（均 P ＜0．05）。试验组总有效率为95．6％，高于对照组的81．8％，Mann -Whitney U 检验结果显示，试验组治疗后临床疗效优于对照组（P ＜0．05），两组不良事件发生率无显著性差异（P ＞0．05）。结论：肠炎宁胶囊联合美沙拉嗪治疗溃疡性结肠炎的临床疗效优于单用美沙拉嗪，值得临床推广应用。
目的：探討腸炎寧膠囊聯閤美沙拉嗪治療潰瘍性結腸炎的臨床療效。方法：選擇2010年1月～2013年9月在我院住院治療的潰瘍性結腸炎患者89例為研究對象，按就診順序隨機分為試驗組和對照組，試驗組45例給予腸炎寧膠囊聯閤美沙拉嗪治療，對照組44例單用美沙拉嗪治療，對兩組患者的血清 IL -1、IL -8、TNF -α、Fib、MPV 及臨床治療效果進行比較。結果：經過30天的治療，兩組患者血清 IL -1、IL -8、TNF -α、Fib、MPV 均顯著下降（均 P ＜0．05）。試驗組治療後的 IL -1、IL -8、TNF -α、Fib、MPV 均不同程度低于對照組，差異均有統計學意義（均 P ＜0．05）。試驗組總有效率為95．6％，高于對照組的81．8％，Mann -Whitney U 檢驗結果顯示，試驗組治療後臨床療效優于對照組（P ＜0．05），兩組不良事件髮生率無顯著性差異（P ＞0．05）。結論：腸炎寧膠囊聯閤美沙拉嗪治療潰瘍性結腸炎的臨床療效優于單用美沙拉嗪，值得臨床推廣應用。
목적：탐토장염저효낭연합미사랍진치료궤양성결장염적림상료효。방법：선택2010년1월～2013년9월재아원주원치료적궤양성결장염환자89례위연구대상，안취진순서수궤분위시험조화대조조，시험조45례급여장염저효낭연합미사랍진치료，대조조44례단용미사랍진치료，대량조환자적혈청 IL -1、IL -8、TNF -α、Fib、MPV 급림상치료효과진행비교。결과：경과30천적치료，량조환자혈청 IL -1、IL -8、TNF -α、Fib、MPV 균현저하강（균 P ＜0．05）。시험조치료후적 IL -1、IL -8、TNF -α、Fib、MPV 균불동정도저우대조조，차이균유통계학의의（균 P ＜0．05）。시험조총유효솔위95．6％，고우대조조적81．8％，Mann -Whitney U 검험결과현시，시험조치료후림상료효우우대조조（P ＜0．05），량조불량사건발생솔무현저성차이（P ＞0．05）。결론：장염저효낭연합미사랍진치료궤양성결장염적림상료효우우단용미사랍진，치득림상추엄응용。
Objective:To evaluate the clinical efficacy of Changyanning capsule combined with mesalazine in the treatment of ulcerative colitis.Methods:89 patients with ulcerative colitis from January 2010 to September 2013 in our hospital were for the study, and they were randomly divided into a treatment group and a control group according to visiting se -quence.45 patients in the treatment group were given Changyanning capsules with mesalazine treatment ,and in the con-trol group 44 cases were given mesalazine treatment .Serum IL -1, IL -8, TNF -α, Fib, MPV and clinical outcomes in both groups were compared.Results:After treatment for 30 d, the serum IL -1, IL -8, TNF -α, Fib, MPV were significantly decreased in both groups(P <0.05),but IL -1, IL -8, TNF -α, Fib, MPV in the treatment group were lower than those in the control group , and the differences were statistically significant (P <0.05).In the treatment group the total effective rate was 95.6%, which was higher than 81.8% in the control group.Mann -Whitney U test showed that the clinical efficacy of the treatment group was superior to that in the control group (P <0.05),and the in-cidence of adverse events in two groups had no significant difference (P >0.05).Conclusion:The clinical efficacy of Changyanning capsule combined with mesalazine in the treatment of ulcerative colitis is better than single mesalazine , which is worthy of clinical application.
