中医药学报
中醫藥學報
중의약학보
ACTA CHINESE MEDICINE AND PHARMACOLOGY
2014年
4期
108-111
,共4页
刘杨%林一帆%赵明宏%陆宇平%高文艳%巩阳%雷春红%盛天骄%李禹廷%吴卓霖%陈山泉
劉楊%林一帆%趙明宏%陸宇平%高文豔%鞏暘%雷春紅%盛天驕%李禹廷%吳卓霖%陳山泉
류양%림일범%조명굉%륙우평%고문염%공양%뢰춘홍%성천교%리우정%오탁림%진산천
消化性溃疡%寒凝血瘀%冬胃颗粒%幽门螺杆菌
消化性潰瘍%寒凝血瘀%鼕胃顆粒%幽門螺桿菌
소화성궤양%한응혈어%동위과립%유문라간균
PU%Cold obstruction causing blood stasis%Dongwei granule%Hp
目的：观察冬胃颗粒联合奥美拉唑、铋剂、三联治疗寒凝血瘀型消化性溃疡的疗效与安全性。方法：66例寒凝血瘀型消化性溃疡患者随机分为两组，实验组（n ＝33），给予冬胃颗粒8g 3次/日＋奥美拉唑40mg 1次/日＋铋剂220mg 3次/日；对照组（n ＝33），给予阿莫西林500mg 3次/日＋甲硝唑0．2 g 3次/日＋奥美拉唑40mg 3次/日＋铋剂220mg 3次/日。以上药物除抗生素服用2周停药，其他药物服至6周结束，第7周复查胃镜和14 C -尿素呼气实验。结果：在临床症状方面，三联使用“冬胃颗粒”在腹痛指标的评价上优于对照组（P ＜0．01），主要差异表现在治疗后第2周；在泛酸、嗳气、纳差三项指标两组未见显著差异（P ＞0．05）。虽然实验组 HP 根除率（58．8％）略低于对照组（71．5％）（P ＜0．05），但其溃疡愈合率（86．6％）与 S2期获得率（61．5％）与对照组比较（85．8％、60．8％），差异无统计学意义（P ＞0．05）。两组均未见明显副作用。结论：冬胃颗粒三联疗法可有效治疗寒凝血瘀型消化性溃疡，腹痛症状的缓解较传统三联疗法快且彻底，且无明显副作用，溃疡治愈率与传统三联疗法相似。
目的：觀察鼕胃顆粒聯閤奧美拉唑、鉍劑、三聯治療寒凝血瘀型消化性潰瘍的療效與安全性。方法：66例寒凝血瘀型消化性潰瘍患者隨機分為兩組，實驗組（n ＝33），給予鼕胃顆粒8g 3次/日＋奧美拉唑40mg 1次/日＋鉍劑220mg 3次/日；對照組（n ＝33），給予阿莫西林500mg 3次/日＋甲硝唑0．2 g 3次/日＋奧美拉唑40mg 3次/日＋鉍劑220mg 3次/日。以上藥物除抗生素服用2週停藥，其他藥物服至6週結束，第7週複查胃鏡和14 C -尿素呼氣實驗。結果：在臨床癥狀方麵，三聯使用“鼕胃顆粒”在腹痛指標的評價上優于對照組（P ＜0．01），主要差異錶現在治療後第2週；在汎痠、噯氣、納差三項指標兩組未見顯著差異（P ＞0．05）。雖然實驗組 HP 根除率（58．8％）略低于對照組（71．5％）（P ＜0．05），但其潰瘍愈閤率（86．6％）與 S2期穫得率（61．5％）與對照組比較（85．8％、60．8％），差異無統計學意義（P ＞0．05）。兩組均未見明顯副作用。結論：鼕胃顆粒三聯療法可有效治療寒凝血瘀型消化性潰瘍，腹痛癥狀的緩解較傳統三聯療法快且徹底，且無明顯副作用，潰瘍治愈率與傳統三聯療法相似。
목적：관찰동위과립연합오미랍서、필제、삼련치료한응혈어형소화성궤양적료효여안전성。방법：66례한응혈어형소화성궤양환자수궤분위량조，실험조（n ＝33），급여동위과립8g 3차/일＋오미랍서40mg 1차/일＋필제220mg 3차/일；대조조（n ＝33），급여아막서림500mg 3차/일＋갑초서0．2 g 3차/일＋오미랍서40mg 3차/일＋필제220mg 3차/일。이상약물제항생소복용2주정약，기타약물복지6주결속，제7주복사위경화14 C -뇨소호기실험。결과：재림상증상방면，삼련사용“동위과립”재복통지표적평개상우우대조조（P ＜0．01），주요차이표현재치료후제2주；재범산、애기、납차삼항지표량조미견현저차이（P ＞0．05）。수연실험조 HP 근제솔（58．8％）략저우대조조（71．5％）（P ＜0．05），단기궤양유합솔（86．6％）여 S2기획득솔（61．5％）여대조조비교（85．8％、60．8％），차이무통계학의의（P ＞0．05）。량조균미견명현부작용。결론：동위과립삼련요법가유효치료한응혈어형소화성궤양，복통증상적완해교전통삼련요법쾌차철저，차무명현부작용，궤양치유솔여전통삼련요법상사。
Objective: To evaluate the clinical efficacy and safeness of Dongwei granule based triple therapy on peptic ul -cer (PU) with cold obstruction causing blood stasis .Method: 66 patients of PU with cold obstruction causing blood sta -sis were selected for random parallel controlled trial .33 cases in the study group were treated with Dongwei granule based triple therapy, Dongwei granule 8g tid plus omeprazole once daily and colloidal Bismuth Pectin 220mg tid, while other 33 patients in the control group were given omeprazole once daily plus colloidal Bismuth Pectin 220mg tid plus Amoxicillin 500mg tid plus metronidazole 40mg tid.The antibiotics above were taken for two weeks , and others were for six weeks.Gastroscopy and 14 C -UBT were rechecked on the seventh week .Results:The evaluation of curative effect of Dongwei granule based triple therapy in abdominal pain gained an advantage over that in the control group after the sec -ond week (P <0.01); there was no statistical significance of curative effect between two groups in belching , anorexia and water brash (P >0.05);the eradication rate of HP in the study group(58.8%) was a little bit lower than that in the control group(71.5%)(P <0.05),nevertheless, the healing rate of the ulcer and the stage S2 pick -up rate were the same in the two groups (P >0.05); no obvious side effects were found .Conclusion: Dongwei granule based triple therapy could cure PU with cold obstruction causing blood stasis , and quickly relieve the abdominal pain and the recov -ery rate was similar to traditional trigeminy treatment .
