CAJ | 학술논문

目的：优选芍药苷胃漂浮片处方工艺。方法：采用湿法制粒压片法制备芍药苷胃漂浮片，以漂浮性能和体外释放度为评价指标，通过单因素和正交试验确定漂浮片最佳工艺处方。结果：最佳工艺为芍药苷80．00mg， HPMC K15M 45．00mg， NaHCO345．00mg， PVPP 20．00mg，十八醇30．00mg， MCC 135．00mg；起漂时间＜1min，持漂时间＞12h，体外释放行为符合药典规定。结论：采用最佳工艺制备的芍药苷胃漂浮片具有优良的漂浮能力和释药行为，使芍药苷在胃内的滞留时间延长，生物利用度提高。
목적：우선작약감위표부편처방공예。방법：채용습법제립압편법제비작약감위표부편，이표부성능화체외석방도위평개지표，통과단인소화정교시험학정표부편최가공예처방。결과：최가공예위작약감80．00mg， HPMC K15M 45．00mg， NaHCO345．00mg， PVPP 20．00mg，십팔순30．00mg， MCC 135．00mg；기표시간＜1min，지표시간＞12h，체외석방행위부합약전규정。결론：채용최가공예제비적작약감위표부편구유우량적표부능력화석약행위，사작약감재위내적체류시간연장，생물이용도제고。
Objective: To optimize formula of gastric floating tablets of total glucosides from paeoniflorin .Methods: Gastric floating tablets were prepared by compression with wet legal system grain .With floating properties and in vitro release as indexes,single factor tests and orthogonal design test were adopted to optimize formulation parameters .Results: Optimum formulation included 80.00mg paeoniflorin, 45.00mg HPMC K15M,45.00mg NaHCO3 ,20.00mg PVPP,30.00mg octa-decanol, 135.00mg MCC.The results showed that these products could float within 1min and maintain for over 12h,in vitro release of this tablets was in accordance with the Chinese Pharmacopoeia demands .Conclusion: These prepared gas-tric floating tablets showed a good sustained -release and continual floating property .It could increase residence time and improve biological availability.