CAJ | 학술논문

目的：了解天津市宝坻区2011-2013年手足口病主要病原型别及其分布特征,为手足口病的防控提供病原学依据。方法采用荧光RT-PCR方法,对采集的临床诊断的手足口病病例粪便样本进行检测和型别鉴定。结果157例临床诊断手足口病病例粪便标本中检出132例EV阳性病例,阳性率为84.08%,其中EV71阳性51例, CA6阳性38例,分别占EV阳性病例的38.64%、28.79%,占所有感染者的85.61%,不同性别间EV71、 CA16、 CA6、其他肠道病毒、 CA16和其他肠道病毒混合感染阳性率差异无统计学意义,2011-2013年病原构成呈动态变化特征,不同病原交替主导。结论2011-2013年宝坻区手足口病的主要病原为EV71和CA6,病原交替主导,存在混合感染,应长期性、连续性地开展病原学监测。
목적：료해천진시보지구2011-2013년수족구병주요병원형별급기분포특정,위수족구병적방공제공병원학의거。방법채용형광RT-PCR방법,대채집적림상진단적수족구병병례분편양본진행검측화형별감정。결과157례림상진단수족구병병례분편표본중검출132례EV양성병례,양성솔위84.08%,기중EV71양성51례, CA6양성38례,분별점EV양성병례적38.64%、28.79%,점소유감염자적85.61%,불동성별간EV71、 CA16、 CA6、기타장도병독、 CA16화기타장도병독혼합감염양성솔차이무통계학의의,2011-2013년병원구성정동태변화특정,불동병원교체주도。결론2011-2013년보지구수족구병적주요병원위EV71화CA6,병원교체주도,존재혼합감염,응장기성、련속성지개전병원학감측。
Objective To analyze the etiological characteristics of hand, foot and mouth disease ( HFMD) in Baodi from 2011 to 2013, and to provide etiological basis for further control and prevention of HFMD. Methods The stool samples collected from pa-tients with HFMD were detected and identified by fluorescent RT- PCR method. Results 132 EV cases of the 157 stool samples of HFMD cases were detected to be positive, and the positive rate was 84.08%, of which 51 EV71 cases were positive, 38 CA6 cases were positive, accounting for 38.64% and 28.79% of EV positive cases, and 85.61% of all the infected respectively. There were no statistic significance as for the differences of infection positive rates among EV71, CA16, CA6 in different genders and other enterovirus and the mixed infection between CA16 and other enterovirus. The pathogen compositions from 2011 to 2013 was dynamic, and they dominated alternatively. Conclusion The major pathogens of HFMD in Baodi District from 2011 to 2013 were EV71 and CA6, which dominated alternatively and posed the possibility of mixed infection, thus, the long-term and continuous etiological surveillance for HFMD should be carried out.