CAJ | 학술논문

采用免疫组织化学的方法研究了速激肽1型受体(NK1R)在斑胸草雀脑干发声控制核团和部分听觉中枢内的分布及阳性标记特征。结果显示,NK1R广泛分布于斑胸草雀发声控制核团和部分听觉中枢内；1)发声控制相关核团：中脑丘间复合体背内侧核(DM)有大量的 NK1R免疫阳性胞体标记,极少出现纤维；中脑腹侧被盖区(VTA)、黑质致密部(SNc)及周围脑区有大量的 NK1R阳性胞体和 NK1R免疫阳性纤维分布；2)听觉中枢：中脑背外侧核(MLd)和耳蜗核前庭外侧核(NM)有密集的胞体标记；而耳蜗核层状核(NL)及角核(NA)有少量 NK1R 阳性胞体分散分布,且角核可见大量密集深染纤维。本实验结果提示 NK1R可能在鸣禽的发声控制及听觉中枢内具有重要的生理功能。
채용면역조직화학적방법연구료속격태1형수체(NK1R)재반흉초작뇌간발성공제핵단화부분은각중추내적분포급양성표기특정。결과현시,NK1R엄범분포우반흉초작발성공제핵단화부분은각중추내；1)발성공제상관핵단：중뇌구간복합체배내측핵(DM)유대량적 NK1R면역양성포체표기,겁소출현섬유；중뇌복측피개구(VTA)、흑질치밀부(SNc)급주위뇌구유대량적 NK1R양성포체화 NK1R면역양성섬유분포；2)은각중추：중뇌배외측핵(MLd)화이와핵전정외측핵(NM)유밀집적포체표기；이이와핵층상핵(NL)급각핵(NA)유소량 NK1R 양성포체분산분포,차각핵가견대량밀집심염섬유。본실험결과제시 NK1R가능재명금적발성공제급은각중추내구유중요적생리공능。
Immunohistochemistry was used to characterize neurokinin-1 receptor (NK1R)distribution in vocal control-related nucleus and auditory nucleus in the brain stem of adult male zebra finch.It was found that NK1R was distributed widely in vocal control-related nucleus and in auditory pathway in the brain stem of adult male zebra finch.Abundant NK1R immunopositive soma but few fibers were identified in vocal control nuclei DM (dorsomedial nucleus of intercollicular complex).Numerous NK1R-positive soma and fibers were found in vocal control nuclei VTA (ventral tegmental area)and SNc (substantia nigra compacta)as well as encephalic regions around them in midbrain.Intensive NK1R-positive soma were found in auditory center nucleus MLd (mesencephalicus lateralis pars dorsalis)and cochlear nucleus NM (nucleus magnocellularis).A few labeled soma were dispersed in cochlear nucleus NL (nucleus laminaris)and in NA (nucleus angularis),abundant strongly labeled fibers were found in NA.These data suggest that NK1R plays an important physiological role in vocal production and auditory perception.