CAJ | 학술논문

目的：探讨电针曲池穴、神门穴对心肌肥厚模型大鼠一氧化氮含量的影响。方法：50只SD大鼠随机分为假手术组、模型组、曲池组、神门组、曲池＋神门组，每组10只，建立腹主动脉缩窄法心肌肥厚大鼠模型，电针采用连续波，连续治疗14天，观察各组全心重量指数和左心室重量指数。硝酸还原酶法测定血浆及左心室匀浆中NO含量。结果：曲池＋神门组与模型组相比能显著降低大鼠全心重量指数及左心室重量指数（ P＜0．05），曲池组、神门组、曲池＋神门组的心肌组织和血清NO含量治疗后与模型组相比有显著性差异（P＜0．05）。结论：电针曲池＋神门可以明显抑制腹主动脉缩窄法引起的心肌肥厚，分子生物学的机制可能是通过升高NO进而发挥抗心肌肥厚的作用。
목적：탐토전침곡지혈、신문혈대심기비후모형대서일양화담함량적영향。방법：50지SD대서수궤분위가수술조、모형조、곡지조、신문조、곡지＋신문조，매조10지，건립복주동맥축착법심기비후대서모형，전침채용련속파，련속치료14천，관찰각조전심중량지수화좌심실중량지수。초산환원매법측정혈장급좌심실균장중NO함량。결과：곡지＋신문조여모형조상비능현저강저대서전심중량지수급좌심실중량지수（ P＜0．05），곡지조、신문조、곡지＋신문조적심기조직화혈청NO함량치료후여모형조상비유현저성차이（P＜0．05）。결론：전침곡지＋신문가이명현억제복주동맥축착법인기적심기비후，분자생물학적궤제가능시통과승고NO진이발휘항심기비후적작용。
Objective:To discuss the effect of electroacupuncture at Quchi ,Shenmen on NO in rats with cardiac hypertrophy .Methods:Fifty SD rats were randomly divided into five groups by random as sham operation group , model group ,Quchi group ,Shenmen group ,Quchi plus Shenmen group , with ten rats in each group .The cardiac hypertrophy model of rat was prepared by transverse aortic coarctation , and rats in electroacupuncture group were received a continuous wave for successive 14 days .The heart mass index and the left ventricular mass in-dex were measured .Through the method of nitric acid reductase , the concentration of NO in blood plasma and heart was detected .Results:Compared with model group ,the heart mass index and the left ventricular mass in-dex were significantly lower with electro -acupuncturing at Quchi and Shenmen ( P<0.05 ) .After the treat-ment,the concentration of NO in blood plasma and heart was significantly higher in Quchi group , Shenmen group and Quchi puls Shenmen group than that in model group (P<0.05).Conclusion:Electroacupuncture at Quchi and Shenmen points can prevent the myocardial hypertrophy constructed through abdominal aortic ban -ding by improving the content of NO .