CAJ | 학술논문

目的：观察电针胰俞穴对2型糖尿病大鼠血清血脂、胰岛素、胰岛素敏感指数、脂联素水平的影响，从而探讨电针胰俞穴治疗2型糖尿病的可能机制。方法：将30只雄性Wistar大鼠随机分为正常组（8只）和2型糖尿病造模组（22只），造模成功后根据血糖水平随机区组分为模型组8只，电针胰俞组8只。治疗4周，每周末检测空腹血糖（ FBG）和体重。4周后取血清，以生化法检测甘油三酯（ TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）水平；以放免法检测空腹胰岛素（FIS）、脂联素（ APN）水平；计算胰岛素敏感指数。结果：与正常组相比，模型组FBG、TC、HDL-C、LDL-C水平均显著升高（ P＜0．05）；体重、ISI、APN均显著下降（ P＜0．05）。与模型组相比，电针胰俞组TC、LDL-C水平均下降，但差异无统计学意义；FBG、体重、TG、HDL-C、脂联素水平显著下降（ P＜0．05）；ISI显著升高（ P＜0．05）。结论：电针胰俞穴可降低2型糖尿病大鼠空腹血糖、血清血脂和脂联素水平，提高胰岛素敏感指数。
목적：관찰전침이유혈대2형당뇨병대서혈청혈지、이도소、이도소민감지수、지련소수평적영향，종이탐토전침이유혈치료2형당뇨병적가능궤제。방법：장30지웅성Wistar대서수궤분위정상조（8지）화2형당뇨병조모조（22지），조모성공후근거혈당수평수궤구조분위모형조8지，전침이유조8지。치료4주，매주말검측공복혈당（ FBG）화체중。4주후취혈청，이생화법검측감유삼지（ TG）、총담고순（TC）、고밀도지단백（HDL-C）、저밀도지단백（LDL-C）수평；이방면법검측공복이도소（FIS）、지련소（ APN）수평；계산이도소민감지수。결과：여정상조상비，모형조FBG、TC、HDL-C、LDL-C수평균현저승고（ P＜0．05）；체중、ISI、APN균현저하강（ P＜0．05）。여모형조상비，전침이유조TC、LDL-C수평균하강，단차이무통계학의의；FBG、체중、TG、HDL-C、지련소수평현저하강（ P＜0．05）；ISI현저승고（ P＜0．05）。결론：전침이유혈가강저2형당뇨병대서공복혈당、혈청혈지화지련소수평，제고이도소민감지수。
Objective:To investigate the effects of electro -acupuncture at EX -B3 on serum lipid,FIS,ISI and APN of T2DM rats,then to discuss the mechanism of electro -acupuncture at EX -B3 on T2DM.Meth-ods:Thirty male wistar rats were randomly divided into a normal control ( including 8 rats) group and a T2DM modeling group(including 22 rats),then the rats of T2DM were divided into model control group and electro -acupuncture at EX -B3 group according to their fast blood glucose ,with each group containing 8 rats.Interfere with electro-acupuncture for four weeks and then extract blood serum ,measure TG,TC,HDL-C and LDL-C with biochemical process ,while measure FIS and APN with radioimmunoassay ,and calculate insulin sensitivity index.Results:Compared with the normal control group ,the levels of FBG,TC,HDL-C,LDL-C of rats in model control group elevated obviously (P<0.05),and the levels of body weight,ISI and APN declined obvi-ously(P<0.05).Compared with the model control group ,the levels of TC,LDL-C of rats in model electro -acupuncture group declined but without statistical significance ,while the levels of FBG ,body weight ,TC,HDL-C,APN declined obviously(P<0.05),and the level of ISI rose obviously (P<0.05).Conclusion:Electro-acupuncture at EX -B3 can decline the levels of FBG ,serum lipid and APN and can improve ISI of T 2 DM rats.