CAJ | 학술논문

目的：比较生长抑素与甲基强的松龙两种冲击疗法治疗活动性Grave’s眼病的疗效和安全性。方法采用随机双盲法将42例Grave，s眼病患者分为先用生长抑素冲击治疗（20例）或先用甲基强的松龙冲击治疗（22例）后用口服泼尼松治疗两组。生长抑素治疗组给予生长抑素2~3mg加入生理盐水500ml中静脉滴注，1次/d连续10d，甲基强的松龙治疗组给予甲基强的松龙15mg/kg加入生理盐水500ml中静脉滴注，隔日1次，连续3次，总剂量不超过4.5~6.0g，两组均于第3周起改为口服泼尼松40mg/d，连用2周后逐渐减量。结果生长抑素治疗组的眼睑挛缩和临床活动性评分（CAS）降低均优于甲基强的松龙治疗组（P<0.05），突眼度改善两组差异无统计学意义；显效率生长抑素治疗组80%，甲基强的松龙治疗组68.2%。结论生长抑素冲击治疗活动性Graves，眼病较甲基强的松龙冲击治疗有效且安全。
목적：비교생장억소여갑기강적송룡량충충격요법치료활동성Grave’s안병적료효화안전성。방법채용수궤쌍맹법장42례Grave，s안병환자분위선용생장억소충격치료（20례）혹선용갑기강적송룡충격치료（22례）후용구복발니송치료량조。생장억소치료조급여생장억소2~3mg가입생리염수500ml중정맥적주，1차/d련속10d，갑기강적송룡치료조급여갑기강적송룡15mg/kg가입생리염수500ml중정맥적주，격일1차，련속3차，총제량불초과4.5~6.0g，량조균우제3주기개위구복발니송40mg/d，련용2주후축점감량。결과생장억소치료조적안검련축화림상활동성평분（CAS）강저균우우갑기강적송룡치료조（P<0.05），돌안도개선량조차이무통계학의의；현효솔생장억소치료조80%，갑기강적송룡치료조68.2%。결론생장억소충격치료활동성Graves，안병교갑기강적송룡충격치료유효차안전。
ObjectiveTo Compare the efficacy and safety of somatostatin and methyl prednisone shock therapy on Graves' ophthalmopathy. Methods42 case of active Graves' ophthalmopathy cases were divided into control group(meprednisone group, n=22)and treatment group(somatostatin group,n=20).Every patient in control group were given methyl prednisolone15 mg/kg/d through intervenous drip every other day for 3 times,the total dose were not more than 4.5 ~ 6.0 g. Patients in treatment group were given somatostatin 2~3 mg/d through intervenous drip for 10 days. Since the third week,two groups were changed to oral prednisone 40 mg/d. Result In improvement of eyelid contracture and clinical activity scores(CAS),somatostatin group had better result than methylprednisolone group(P<0.05). There were no significant difference in Degree of exophthalmus and obvious effective rates between the two groups(P>0.05);Methylprednisolone group efficiency 68.2%,somatostatin group efficiency 80%. ConclusionComparing with methylprednisolone treatment,short-range somatostatin treatment is effecient and safe on active Graves' ophthalmopathy.