针灸临床杂志
針灸臨床雜誌
침구림상잡지
JOURNAL OF CLINICAL ACUPUNCTURE AND MOXIBUSTION
2014年
8期
40-43
,共4页
泛发性皮肤瘙痒症%自血穴位注射%免疫偏移
汎髮性皮膚瘙癢癥%自血穴位註射%免疫偏移
범발성피부소양증%자혈혈위주사%면역편이
Generalized pruritus%Self-blood acupoint injection%Immune deviation
目的：观察自血穴位注射对泛发性皮肤瘙痒症患者的临床疗效及其对Th1/Th2免疫偏移的影响。方法：66例患者完全随机分为两组。治疗组33例在口服氯雷他定基础上加用自血穴位注射疗法，对照组33例仅应用基础治疗，即口服氯雷他定，两组疗程均为4周。疗程结束后，观测两组症状变化，采用双抗夹心ELISA法检测两组治疗前后Th1细胞因子IFN-γ、IL-2与Th2细胞因子IL-4、IL-10水平变化。结果：治疗后两组症状均有好转，但治疗组明显优于对照组（ P＜0．05）；治疗组治疗后IFN-γ与IL-2水平均较治疗前明显降低（P＜0．05），且明显低于对照组治疗后（P＜0．05），治疗组治疗后IL-4与IL-10水平均较治疗前明显升高（P＜0．05），且明显高于对照组治疗后（P＜0．05）。结论：自血穴位注射对泛发性皮肤瘙痒症有良好的疗效，可能是通过调节Th1/Th2细胞因子水平，改善了免疫偏移状态而达到治疗目的。
目的：觀察自血穴位註射對汎髮性皮膚瘙癢癥患者的臨床療效及其對Th1/Th2免疫偏移的影響。方法：66例患者完全隨機分為兩組。治療組33例在口服氯雷他定基礎上加用自血穴位註射療法，對照組33例僅應用基礎治療，即口服氯雷他定，兩組療程均為4週。療程結束後，觀測兩組癥狀變化，採用雙抗夾心ELISA法檢測兩組治療前後Th1細胞因子IFN-γ、IL-2與Th2細胞因子IL-4、IL-10水平變化。結果：治療後兩組癥狀均有好轉，但治療組明顯優于對照組（ P＜0．05）；治療組治療後IFN-γ與IL-2水平均較治療前明顯降低（P＜0．05），且明顯低于對照組治療後（P＜0．05），治療組治療後IL-4與IL-10水平均較治療前明顯升高（P＜0．05），且明顯高于對照組治療後（P＜0．05）。結論：自血穴位註射對汎髮性皮膚瘙癢癥有良好的療效，可能是通過調節Th1/Th2細胞因子水平，改善瞭免疫偏移狀態而達到治療目的。
목적：관찰자혈혈위주사대범발성피부소양증환자적림상료효급기대Th1/Th2면역편이적영향。방법：66례환자완전수궤분위량조。치료조33례재구복록뢰타정기출상가용자혈혈위주사요법，대조조33례부응용기출치료，즉구복록뢰타정，량조료정균위4주。료정결속후，관측량조증상변화，채용쌍항협심ELISA법검측량조치료전후Th1세포인자IFN-γ、IL-2여Th2세포인자IL-4、IL-10수평변화。결과：치료후량조증상균유호전，단치료조명현우우대조조（ P＜0．05）；치료조치료후IFN-γ여IL-2수평균교치료전명현강저（P＜0．05），차명현저우대조조치료후（P＜0．05），치료조치료후IL-4여IL-10수평균교치료전명현승고（P＜0．05），차명현고우대조조치료후（P＜0．05）。결론：자혈혈위주사대범발성피부소양증유량호적료효，가능시통과조절Th1/Th2세포인자수평，개선료면역편이상태이체도치료목적。
Objective:To observe the clinical effect of acupoint injection with self -blood therapy on general-ized pruritus and the impact on serum levels of Th 1/Th2 cytokine .Methods:66 patients with generalized pruri-tus were equally randomized into two groups .The patients in the treatment group ( 33 cases ) were treated by acupoint injection with self -blood therapy on the basis of oral loratadine , and those in the control group ( 33 cases) were given oral loratadine,and the treatment in two groups was for 4 weeks.Changes of symptoms and se-rum levels of Th1 cytokine:IFN-γ,IL-2 and Th2 cytokine:IL-4,IL-10 were observed before and after treatment.Results:The curative effect in the treatment group was better than that in the control group ( P<0.05 ) .Levels of IFN-γand IL-2 in the treatmeat group were significantly lower after treatment ( P<0.05 ) , and they were lower than those in the control group ( P<0 .05 ) ;Levels of IL-4 and IL-10 in the treatment group were significantly heightened after treatment (P<0.05), and they were higher than those in the control group (P<0.05).Conclusion:Acupoint injection with self -blood therapy shows a favorite effect on treating generalized pruritus and it may be achieved by regulating Th 1/Th2 cytokine levels to improve the immune sta-tus.
