CAJ | 학술논문

目的：观察人脐带间充质干细胞静脉输注治疗失代偿期肝硬化的临床疗效及安全性。方法将65例失代偿期肝硬化患者随机分为两组，治疗组40例，对照组25例，对照组给予综合护肝、支持对症治疗，治疗组在对照组治疗基础上，通过外周静脉输注脐带血干细胞悬液100 ml，每周1次静脉输注，连续3次。分别观察两组治疗前及治疗后4周、8周、12周24周，患者的临床症状、肝功能、凝血功能、肝纤维化等指标变化。结果治疗组经人脐带间充质干细胞治疗后4周，白蛋白和凝血功能较治疗前明显改善，12周肝硬度值下降。临床症状和体征改善明显。结论外周静脉输注人脐带间充质干细胞治疗失代偿期肝硬化，近期可明显改善肝功能，提升白蛋白、改善凝血功能、改善肝纤维化程度等，可提高患者生存率。
목적：관찰인제대간충질간세포정맥수주치료실대상기간경화적림상료효급안전성。방법장65례실대상기간경화환자수궤분위량조，치료조40례，대조조25례，대조조급여종합호간、지지대증치료，치료조재대조조치료기출상，통과외주정맥수주제대혈간세포현액100 ml，매주1차정맥수주，련속3차。분별관찰량조치료전급치료후4주、8주、12주24주，환자적림상증상、간공능、응혈공능、간섬유화등지표변화。결과치료조경인제대간충질간세포치료후4주，백단백화응혈공능교치료전명현개선，12주간경도치하강。림상증상화체정개선명현。결론외주정맥수주인제대간충질간세포치료실대상기간경화，근기가명현개선간공능，제승백단백、개선응혈공능、개선간섬유화정도등，가제고환자생존솔。
ObjectiveTo invstigate theclinic effects and safety of human Umbilical cord mesenchymal stem cells(UCMSCs) transplantation in treatment of patients with decompensated liver cirrhosis.Methods65 patients with decompensated liver cirrhosis were involved and divided into 2 groups.20 patients in the control group were treated with conventional therapy while 40 patients were received UCSCs transplantation via peripheraily venous based on conventional therapy,with 100 ml of UCSCs suspension once a week for 3 weeks.The clinical symptoms,serum ALT,Alb,Tbil,PT,and liver stifiness were determined before at week 0,4, 8,12,and 24 post the UCMSCs treatment.ResultsSerum markers of liver function and blood coagulation function before and after treatment of 40 cases were significantly different(P<0.05),liver fibrosis decline after 12 weeks.The differences in clinical symptoms and signs between the 2 groups were significant.ConclusionsThe transplantation of UC-MSCs via peripheraily vein is effective in short time for treatment of patients with decompensated liver cirrhosis.