CAJ | 학술논문

目的：探讨胶体金法检测血与尿胱抑素 C 在糖尿病早期肾损伤中的意义。方法通过检测114例正常人与116例糖尿病患者血及尿中胱抑素 C（Cys C）与β2微球蛋白（β2-MG），采用对比分析，评价正常人群清晨随机尿中尿胱抑素 C 水平，以及不同糖尿病组（尿微量白蛋白正常及异常组）血、尿胱抑素 C 与血、尿β2微球蛋白之间的关系。结果在糖尿病早期肾损伤中检测血或尿胱抑素 C 与检测血及尿β2微球蛋白，经过对比分析，二者均有显著的正相关性；但是单独检测尿胱抑素 C，与尿β2微球蛋白相比，二者间没有统计学差别。结论在糖尿病早期肾损伤中检测血或尿胱抑素 C 同样是一个理想的诊断指标。
목적：탐토효체금법검측혈여뇨광억소 C 재당뇨병조기신손상중적의의。방법통과검측114례정상인여116례당뇨병환자혈급뇨중광억소 C（Cys C）여β2미구단백（β2-MG），채용대비분석，평개정상인군청신수궤뇨중뇨광억소 C 수평，이급불동당뇨병조（뇨미량백단백정상급이상조）혈、뇨광억소 C 여혈、뇨β2미구단백지간적관계。결과재당뇨병조기신손상중검측혈혹뇨광억소 C 여검측혈급뇨β2미구단백，경과대비분석，이자균유현저적정상관성；단시단독검측뇨광억소 C，여뇨β2미구단백상비，이자간몰유통계학차별。결론재당뇨병조기신손상중검측혈혹뇨광억소 C 동양시일개이상적진단지표。
Objective To detect cystatin C with liquid immune colloidal gold technique in serum and urine and study the significance in early renal injury of patients with Diabetes Mellitus.Methods we detected cystatin C(Cys C)with liquid immune colloidal gold technique and compared withβ2 -microglobulin (β2-MG)in serum and urine for 114 nor-mal people and 116 patients with Diabetes Mellitus,then evaluated the level of random urine Cys C for normal people in the morning and the relationship of Cys C and β2-MG in different patients groups with Diabetes Mellitus(normal and unnormal mALB).Results It had a significant positive correlation by statistal analysis for detecting Cys C andβ2-MG in serum and urine of patients with early renal injury of Diabetes Mellitus;but there is no statistical difference between only detecting urine Cys C andβ2-MG.Conclusion It will be an ideal diagnostic indicator for detecting serum and urine Cys C in patients with early renal injury of Diabetes Mellitus .