CAJ | 학술논문

目的：探讨乙肝患者血清中的 TNF-α、IL-6、IL-10的表达水平及临床意义。方法选取2009年1月-2012年12月在本院进行治疗的128例乙型肝炎患者为病例组，其中包括急性乙型肝炎患者14例，轻度慢性乙性肝炎患者29例，中度慢性乙性肝炎患者34例，重度慢性乙性肝炎患者24例，乙肝后肝硬化患者27例，同时选择进行体检的40名健康人为对照组，将两组人的血清 TNF-α、IL-6、及 IL-10含量进行测量和分析。结果病例组血清 TNF-α和 IL-6含量高于对照，随着病程的进展血清 TNF-α及 IL-6的含量上升，病例组血清 IL-10含量低于对照组。P ＜0．05，有显著性差异。结论乙肝患者血清 TNF-α、IL-6均呈现升高的状态，而 IL-10呈降低的状态，其含量变化可预测病情进展及病情的严重程度。
목적：탐토을간환자혈청중적 TNF-α、IL-6、IL-10적표체수평급림상의의。방법선취2009년1월-2012년12월재본원진행치료적128례을형간염환자위병례조，기중포괄급성을형간염환자14례，경도만성을성간염환자29례，중도만성을성간염환자34례，중도만성을성간염환자24례，을간후간경화환자27례，동시선택진행체검적40명건강인위대조조，장량조인적혈청 TNF-α、IL-6、급 IL-10함량진행측량화분석。결과병례조혈청 TNF-α화 IL-6함량고우대조，수착병정적진전혈청 TNF-α급 IL-6적함량상승，병례조혈청 IL-10함량저우대조조。P ＜0．05，유현저성차이。결론을간환자혈청 TNF-α、IL-6균정현승고적상태，이 IL-10정강저적상태，기함량변화가예측병정진전급병정적엄중정도。
Objective To explore the clinical significance of changes on serum levels of TNF-α,interleukin-6 (IL-6) the clinical significance of changes on serum levels of inter and interleukin-10 (IL-10)in patients with chronic hepatitis B(CHB).the clinical significance of changes on serum levels of inter Methods 128 patients with chronic hepatitis B in our hospital from January 2009 to December 2012 were selected as observation group ,and 40 healthy personnel at the same time were selected as control group,then the content of serum TNF-α、IL-6 and IL-10 of two groups were ana-lyzed and compared.Results The content of serum TNF-αand IL-6 of observation group were all higher than those of control group,With the progression of serum TNF-α andIL-6 increased.The content of serum IL-10 of observation group was lower than those of control group,With the progression of serum IL-10 decreased.all P <0.05,there were all significant differences.Conclusion The serum TNF-α、IL-6 of patients with chronic hepatitis B are all higher,and IL-10 is lower,and it has clinical significance for understanding the severity of disease.