CAJ | 학술논문

目的：探讨 IFN-γ在结核性胸膜炎患者血清中的表达及意义。方法计算机检索 PubMed、Ovid、Elsevier、CNKI、维普、CBM、万方等中英文数据库，检索血清 IFN-γ与结核性胸膜炎的病例-对照研究。按照纳入与排除标准选择研究文献，同时对文献进行质量评价，以加权均数差值（WMD）及其95％CI 为效应评价指标，应用 RevMan5．1进行Meta 分析。结果共有10篇病例对照研究纳入研究，包括结核性胸膜炎426例，恶心胸水323例，其他炎症胸水97例，健康人219例。Meta 分析结果显示：结核性胸膜炎血清 IFN-γ要显著高于恶性胸膜炎[WMD＝5．78，95％ CI （2.82，8．75）]、其他胸膜炎[WMD＝4．66，95％CI 为（0．08，9．24）]及健康人[WMD＝5．24，95％CI 为（3．33，7．15）]。结论血清 INF-γ高表达可能与结核性胸膜炎发病有关联，有望将血清 INF-γ检测应用于结核性胸膜炎的筛查和诊断。
목적：탐토 IFN-γ재결핵성흉막염환자혈청중적표체급의의。방법계산궤검색 PubMed、Ovid、Elsevier、CNKI、유보、CBM、만방등중영문수거고，검색혈청 IFN-γ여결핵성흉막염적병례-대조연구。안조납입여배제표준선택연구문헌，동시대문헌진행질량평개，이가권균수차치（WMD）급기95％CI 위효응평개지표，응용 RevMan5．1진행Meta 분석。결과공유10편병례대조연구납입연구，포괄결핵성흉막염426례，악심흉수323례，기타염증흉수97례，건강인219례。Meta 분석결과현시：결핵성흉막염혈청 IFN-γ요현저고우악성흉막염[WMD＝5．78，95％ CI （2.82，8．75）]、기타흉막염[WMD＝4．66，95％CI 위（0．08，9．24）]급건강인[WMD＝5．24，95％CI 위（3．33，7．15）]。결론혈청 INF-γ고표체가능여결핵성흉막염발병유관련，유망장혈청 INF-γ검측응용우결핵성흉막염적사사화진단。
Objective To study the expression and clinical significance of Interferon-gamma(IFN-Y)in blood serum for tuberculous exadative pleurisy.Methods The original case-control study was retrieved form PUBMED 、Ovid 、Elsevier、CNKI、Weipu database、Wanfang database and so on.The established items were used for the standard of se-lection and quality assessment.Review Manger 5.1 was used to analyze pooled weighted mean difference(WMD)and confidence interval(CI).Results Though literature retrival,ten articles were selected,including 426 patients with tu-bercuous pleurisy,323 patients with malignant pleural effusion,97 patients with other inflammatory effusion and 219 healthy persons.The result indicates IFN-Y in blood serum for tubercuous pleurisy was much higher than malignant pleural effusion[WMD=5.78,95% (2.82,8.75)],other inflammatory effusion[WMD= 4.66,95% (0.08,9.24)], healthy persons[WMD=5.24,95%(3.33,7.15)].Conclusion The high expression of IFN-Y in blood serum may re-lated to tubercuous pleurisy can be used as the means of screening and diagnosis.