CAJ | 학술논문

目的：探讨分析 H-FABP、NT-proBNP、CRP、cTnT 在 ACS 患者预后中的评估价值。方法96例 ACS 患者根据随访1年内患者是否发生不良心血管事件将所有患者分为预后不良组（35例）与对照组（61例）。于患者入院后检测 H-FABP、NT-proBNP、CRP、cTnT 四项指标的水平，并于出院后进行为期1年的随访，绘制受试者工作特性曲线来测定上述四项指标对 ACS 患者预后评估的准确性，并找出出院后发生不良心血管事件的危险因素。结果入院时预后不良组 H-FABP、NT-proBNP、CRP、cTnT 水平均明显高于对照组（P ＜0．05）；H-FABP、NT-proBNP、CRP、cTnT 检测对预测心血管不良事件的 ROC 曲线下面积与临界值分别为0．811、40．95μg/L，0．749、1342．98 ng/L，0.788、9．69 mg/L，0．812、0．78μg/L；COX 单因素回归分析显示 H-FABP、NT-proBNP、CRP 及 cTnT 水平的升高是ACS 患者发生心血管不良事件的危险因素（P ＜0．05）。结论 H-FABP、NT-proBNP、CRP、cTnT 对 ACS 患者的预后有着较高的评估价值，值得推广。
목적：탐토분석 H-FABP、NT-proBNP、CRP、cTnT 재 ACS 환자예후중적평고개치。방법96례 ACS 환자근거수방1년내환자시부발생불양심혈관사건장소유환자분위예후불량조（35례）여대조조（61례）。우환자입원후검측 H-FABP、NT-proBNP、CRP、cTnT 사항지표적수평，병우출원후진행위기1년적수방，회제수시자공작특성곡선래측정상술사항지표대 ACS 환자예후평고적준학성，병조출출원후발생불양심혈관사건적위험인소。결과입원시예후불량조 H-FABP、NT-proBNP、CRP、cTnT 수평균명현고우대조조（P ＜0．05）；H-FABP、NT-proBNP、CRP、cTnT 검측대예측심혈관불량사건적 ROC 곡선하면적여림계치분별위0．811、40．95μg/L，0．749、1342．98 ng/L，0.788、9．69 mg/L，0．812、0．78μg/L；COX 단인소회귀분석현시 H-FABP、NT-proBNP、CRP 급 cTnT 수평적승고시ACS 환자발생심혈관불량사건적위험인소（P ＜0．05）。결론 H-FABP、NT-proBNP、CRP、cTnT 대 ACS 환자적예후유착교고적평고개치，치득추엄。
Objective To study the prognostic value of H-FABP,NT-proBNP,CRP and cTnT in patients with ACS.Methods 96 patients with ACS were divided into the poor prognosis group (35 cases)and control group (61 ca-ses)according to the occurrence of adverse cardiovascular events.Level of H-FABP,NT-proBNP,CRP and cTnT was tested after the admission of the patients.A one-year follow-up was carried out after the discharge and ROC was plotted to determine the accuracy of the four indicators of prognosis of patients with ACS.In the same time,risk factors for ad-verse cardiovascular events were also found out.Results Level of H-FABP,NT-proBNP,CRP and cTnT of poor prog-nosis group was statistically higher than that of the control group (P < 0.05);AUC and cutoff value H-FABP,NT-proBNP,CRP,cTnI detection of adverse cardiovascular events were 0.811,40.95 μg/L,0.749,,1342.98 ng/L,0.788, 9.69 mg/L,0.812,0.78 μg/L;COX analysis showed that COX H-FABP,NT-proBNP,CRP,and elevated cTnT levels in patients with ACS is a risk factor for cardiovascular adverse events(P <0.05).Conclusion H-FABP,NT-proBNP, CRP and cTnT has high prognostic value in patients with ACS,which is worth promoting.