中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
8期
1252-1254
,共3页
脑梗死%血清胱抑素C%基质金属蛋白酶 9%病程%脑卒中
腦梗死%血清胱抑素C%基質金屬蛋白酶 9%病程%腦卒中
뇌경사%혈청광억소C%기질금속단백매 9%병정%뇌졸중
cerebral infarction%serum cystatin C%matrix metalloproteinase 9%course of disease%stroke
目的：通过观察脑梗死患者血清中基质蛋白酶9（MMP-9）和胱抑素 C（Cys-C）的含量水平变化与脑梗死患者病变程度的关系，探讨其在脑梗死发展过程中的作用。方法选择首次发病的48 h 内的急性脑梗死患者83例为研究组。测定患者发病第3、7、14 d 时的血清 MMP-9及 Cys-C 水平。并与52例健康对照者的检测结果进行比较。结果研究组患者血清 MMP-9及 Cys-C 水平均显著高于对照组（t＝11．38，P ＝0．02；t＝13．65，P ＝0．007）。脑梗死损伤重度组患者血清 MMP-9及 Cys-C 水平均显著高于轻微脑梗死组患者（t ＝8．93，9．26，2．75，1．98；P ＝0．008，0.005，0．01，0．04）。大梗死灶组患者血清 MMP-9及 Cys-C 水平显著高于中、小梗死灶组，差异具有统计学意义（P ＜0.05）。且入院3d 时，中梗死灶组患者 MMP-9及 Cys-C 水平均显著高于小梗死灶组，差异具有统计学意义（P ＜0.05）。结论血清 MMP-9及 Cys-C 水平与脑梗死的发生及梗死体积大小、病情严重程度相关。脑梗死早期检测血清 MMP-9及 Cys-C 水平可作为脑梗死的预测因子，是判断脑梗死患者病程转化及近期预后的重要指标。
目的：通過觀察腦梗死患者血清中基質蛋白酶9（MMP-9）和胱抑素 C（Cys-C）的含量水平變化與腦梗死患者病變程度的關繫，探討其在腦梗死髮展過程中的作用。方法選擇首次髮病的48 h 內的急性腦梗死患者83例為研究組。測定患者髮病第3、7、14 d 時的血清 MMP-9及 Cys-C 水平。併與52例健康對照者的檢測結果進行比較。結果研究組患者血清 MMP-9及 Cys-C 水平均顯著高于對照組（t＝11．38，P ＝0．02；t＝13．65，P ＝0．007）。腦梗死損傷重度組患者血清 MMP-9及 Cys-C 水平均顯著高于輕微腦梗死組患者（t ＝8．93，9．26，2．75，1．98；P ＝0．008，0.005，0．01，0．04）。大梗死竈組患者血清 MMP-9及 Cys-C 水平顯著高于中、小梗死竈組，差異具有統計學意義（P ＜0.05）。且入院3d 時，中梗死竈組患者 MMP-9及 Cys-C 水平均顯著高于小梗死竈組，差異具有統計學意義（P ＜0.05）。結論血清 MMP-9及 Cys-C 水平與腦梗死的髮生及梗死體積大小、病情嚴重程度相關。腦梗死早期檢測血清 MMP-9及 Cys-C 水平可作為腦梗死的預測因子，是判斷腦梗死患者病程轉化及近期預後的重要指標。
목적：통과관찰뇌경사환자혈청중기질단백매9（MMP-9）화광억소 C（Cys-C）적함량수평변화여뇌경사환자병변정도적관계，탐토기재뇌경사발전과정중적작용。방법선택수차발병적48 h 내적급성뇌경사환자83례위연구조。측정환자발병제3、7、14 d 시적혈청 MMP-9급 Cys-C 수평。병여52례건강대조자적검측결과진행비교。결과연구조환자혈청 MMP-9급 Cys-C 수평균현저고우대조조（t＝11．38，P ＝0．02；t＝13．65，P ＝0．007）。뇌경사손상중도조환자혈청 MMP-9급 Cys-C 수평균현저고우경미뇌경사조환자（t ＝8．93，9．26，2．75，1．98；P ＝0．008，0.005，0．01，0．04）。대경사조조환자혈청 MMP-9급 Cys-C 수평현저고우중、소경사조조，차이구유통계학의의（P ＜0.05）。차입원3d 시，중경사조조환자 MMP-9급 Cys-C 수평균현저고우소경사조조，차이구유통계학의의（P ＜0.05）。결론혈청 MMP-9급 Cys-C 수평여뇌경사적발생급경사체적대소、병정엄중정도상관。뇌경사조기검측혈청 MMP-9급 Cys-C 수평가작위뇌경사적예측인자，시판단뇌경사환자병정전화급근기예후적중요지표。
Objective To investigate the relationship between levels of serum matrix metalloproteinase 9(MMP-9), cystatin C (Cys-C)and severity of cerebral infarction.Methods 83 patients with acute cerebral infarction onset within 48h were chosen for the study group.Serum MMP-9 and Cys-C levels were measured in 3,7and 14d after admission. The test results were compared with those of 52 healthy controls.Results the serum MMP-9 and Cys-C levels were significantly higher than those in the control group (t=11.38,P =0.02;t=13.65,P =0.007).in severe Cerebral ische-mia group,serum MMP-9 and Cys-C levels were significantly higher than those of mild cerebral infarction patients (t=8.93,9.26,2.75,1.98;P =0.008,0.005,0.01,0.04).Large infarction serum MMP-9 and Cys-C levels were signifi-cantly higher than middle and small infarction group,the difference was statistically significant (P <0.05).3d after ad-mission,MMP-9 and Cys-C levels of middle infarction group were significantly higher than those of small infarction group,the difference was statistically significant (P <0.05).Conclusion the serum MMP-9 and Cys-C levels have cor-relation with the occurrence of cerebral infarction、size of infarction and the severity of the disease.Cerebral infarction early detection of serum MMP-9 and Cys-C levels can be used as predictors of cerebral infarction,are important index to judge the course of transformation in patients with cerebral infarction and short-term prognosis.
