药物不良反应杂志
藥物不良反應雜誌
약물불량반응잡지
ADVERSE DRUG REACTIONS JOURNAL
2014年
4期
248-248
,共1页
克林霉素%血小板减少
剋林黴素%血小闆減少
극림매소%혈소판감소
Clindamycin%Thrombocytopenia
1例3岁男性患儿因溃疡性口炎给予克林霉素0.15 g,1次/d静脉滴注,治疗前血小板计数150×109/L。第1天,患儿左膝关节出现红色瘀斑。第3天,患儿出现齿龈出血及皮肤散在出血点,血小板计数为0,活化部分凝血活酶时间31 s。停用克林霉素,静脉滴注甲泼尼龙(30 mg,1次/d)及人免疫球蛋白(6 g,1次/d),口服氨肽素(0.1 g,3次/d)。第4天,患儿血小板计数64×109/L,活化部分凝血活酶时间16 s,凝血酶原时间11 s。1周后,患儿血小板计数升至135×109/L,瘀斑消退。
1例3歲男性患兒因潰瘍性口炎給予剋林黴素0.15 g,1次/d靜脈滴註,治療前血小闆計數150×109/L。第1天,患兒左膝關節齣現紅色瘀斑。第3天,患兒齣現齒齦齣血及皮膚散在齣血點,血小闆計數為0,活化部分凝血活酶時間31 s。停用剋林黴素,靜脈滴註甲潑尼龍(30 mg,1次/d)及人免疫毬蛋白(6 g,1次/d),口服氨肽素(0.1 g,3次/d)。第4天,患兒血小闆計數64×109/L,活化部分凝血活酶時間16 s,凝血酶原時間11 s。1週後,患兒血小闆計數升至135×109/L,瘀斑消退。
1례3세남성환인인궤양성구염급여극림매소0.15 g,1차/d정맥적주,치료전혈소판계수150×109/L。제1천,환인좌슬관절출현홍색어반。제3천,환인출현치간출혈급피부산재출혈점,혈소판계수위0,활화부분응혈활매시간31 s。정용극림매소,정맥적주갑발니룡(30 mg,1차/d)급인면역구단백(6 g,1차/d),구복안태소(0.1 g,3차/d)。제4천,환인혈소판계수64×109/L,활화부분응혈활매시간16 s,응혈매원시간11 s。1주후,환인혈소판계수승지135×109/L,어반소퇴。
A 3-year-old boy received an IV infusion of clindamycin 0. 15 g twice daily for ulcerative stomatitis. Before giving clindamycin,his platelet count was 150 × 109/L. On day 1,the boy presented with red ecchymosis on left knee joint. On day 3,the boy developed gingival bleeding and skin scattered petechiae, his platelet count was 0 and activated partial thromboplastin time was 31 s. Clindamycin was stopped. IV infusions of methylprednisolone(30 mg,once daily)and human immunoglobulin(6 g,once daily),oral amino-polypeptide(0. 1 g,thrice daily)were given. On day 4,his platelet count was 64 × 109/L,activated partial thromboplastin time was 16 s,prothrombin time was 11 s. After a week,the platelet count returned to 135 × 109/L and ecchymosis disappeared.