CAJ | 학술논문

目的：观察重复经颅磁刺激（ rTMS）治疗前后精神分裂症患者的失匹负波（ MMN）及P300的变化特点。方法对78例精神分裂症患者（精神分裂症组）在rTMS治疗前后进行了P300和MMN检测，观察rTMS治疗前后P300和MMN的变化。另对62名正常对照者（对照组）进行P300和MMN检测，并将两组结果进行比较。结果与对照组相比，精神分裂症组的MMN潜伏期延迟和波幅降低（分别P＜0.05和P＜0.01），P300中的靶波幅P3降低（P＜0.05）。精神分裂症组经过rTMS治疗后，MMN波幅及P300靶波幅P3较治疗前有所恢复（P＜0.05）。结论联合应用P300和MMN，可作为抗精神病药物合并rTMS治疗精神分裂症的疗效监测指标。
목적：관찰중복경로자자격（ rTMS）치료전후정신분렬증환자적실필부파（ MMN）급P300적변화특점。방법대78례정신분렬증환자（정신분렬증조）재rTMS치료전후진행료P300화MMN검측，관찰rTMS치료전후P300화MMN적변화。령대62명정상대조자（대조조）진행P300화MMN검측，병장량조결과진행비교。결과여대조조상비，정신분렬증조적MMN잠복기연지화파폭강저（분별P＜0.05화P＜0.01），P300중적파파폭P3강저（P＜0.05）。정신분렬증조경과rTMS치료후，MMN파폭급P300파파폭P3교치료전유소회복（P＜0.05）。결론연합응용P300화MMN，가작위항정신병약물합병rTMS치료정신분렬증적료효감측지표。
Objective To observe the changes of mismatch negativity ( MMN ) and P300 caused by repetitive transcranial magnetic stimulation ( rTMS ) in patients with schizophrenia . Methods Before and after rTMS treatment, the MMN and P300 were measured in 78 patients with schizophrenia ( the schizophrenia group ) and compared with that in 62 normal controls ( the control group ) . Results Compared with the control groups , the schizophrenia group showed delayed MMN latency ( P <0.05 ) , decreased MMN amplitude ( P <0.01 ) , and decreased target amplitude P 3 of P300 ( P<0.05 ) .After rTMS treatment , the MMN amplitude and target amplitude P3 of P300 in the schizophrenia group increased ( all P <0.05 ) . Conclusion Combination of MMN and P300 measurement can be used as a valuable monitor of the effect of rTMS treatment in patients with schizophrenia .