赣南医学院学报
贛南醫學院學報
공남의학원학보
JOURNAL OF GANNAN MEDICAL COLLEGE
2014年
4期
505-507
,共3页
普卢利沙星%胶囊剂%溶出度%质量控制
普盧利沙星%膠囊劑%溶齣度%質量控製
보로리사성%효낭제%용출도%질량공제
Prulifloxacin%capsule%dissolution rate%quality control
目的：建立普卢利沙星胶囊剂溶出度的测定方法。方法：采用转蓝法，以1000 mL 盐酸溶液（9→1000）为溶出介质，转速：100 r·min -1，45 min 取样，274 nm 波长处分光光度法检测。结果：普卢利沙星在1.2~12.3μg·mL -1浓度范围内线性关系良好（r =0.9999，n =5），平均回收率99.7%，RSD 为0.37%。结论：采用紫外分光光度法测定普卢利沙星胶囊溶出度的方法操作简便，结果准确，能够用于该药的质量控制。
目的：建立普盧利沙星膠囊劑溶齣度的測定方法。方法：採用轉藍法，以1000 mL 鹽痠溶液（9→1000）為溶齣介質，轉速：100 r·min -1，45 min 取樣，274 nm 波長處分光光度法檢測。結果：普盧利沙星在1.2~12.3μg·mL -1濃度範圍內線性關繫良好（r =0.9999，n =5），平均迴收率99.7%，RSD 為0.37%。結論：採用紫外分光光度法測定普盧利沙星膠囊溶齣度的方法操作簡便，結果準確，能夠用于該藥的質量控製。
목적：건립보로리사성효낭제용출도적측정방법。방법：채용전람법，이1000 mL 염산용액（9→1000）위용출개질，전속：100 r·min -1，45 min 취양，274 nm 파장처분광광도법검측。결과：보로리사성재1.2~12.3μg·mL -1농도범위내선성관계량호（r =0.9999，n =5），평균회수솔99.7%，RSD 위0.37%。결론：채용자외분광광도법측정보로리사성효낭용출도적방법조작간편，결과준학，능구용우해약적질량공제。
Obiective:To establish the determination method of dissolution rate of Prulifloxacin Capsules. Methods:The dissolution rate for Prulifloxacin Capsules was detected by using UV spectrophotometry at 274 nm with hydrochloric acid solution(9→1 000)1 000 mL as the dissolution mediator at the rate of 100 r·min - 1 by the stirring basket method,45 min sampling. Results:The calibrated linear curve of Prulifloxacin was good in the range of 1. 2 ~ 12. 3 μg·mL - 1(r =0. 9 999,n = 5). The average recovery rate was 99. 7 % with RSD of 0. 37% . Conclusion:The method is proved to be accurate and reliable for the quality control of Prulifloxacin capsules.
