CAJ | 학술논문

目的：探讨冠心病患者血MMP-9、 NT-proBNP、 hs-CRP水平变化情况，并分析其临床意义。方法选择我院于2011年12月至2013年10月接诊的102例冠心病患者的临床病例资料，包括AMI （急性心肌梗死）31例， UAP （不稳定心绞痛）42例， SAP （稳定性心绞痛）29例，并选择来我院的33例健康体检者作为对照组，探讨冠心病患者血MMP-9、 NT-proBNP、 hs-CRP水平变化及意义。结果 AMI组和UAP组患者的血清MMP-9、 NT-proBNP、 hs-CRP水平均明显高于SAP组和对照组患者的血清水平（ P＜0.05）， AMI组患者的血清MMP-9、 NT-proBNP、 hs-CRP水平均明显高于UAP组患者的血清水平（P＜0.05），而且，随着冠脉病变支数的增加，患者的血清MMP-9、 NT-proBNP、 hs-CRP水平也不断增加，差异有统计学意义（P＜0.05）。结论血清MMP-9、 NT-proBNP、 hs-CRP水平与冠心病患者的病情严重程度密切相关，可能在一定程度上预示着冠心病患者的病情严重程度，具有十分重要的临床意义，值得临床参考。
목적：탐토관심병환자혈MMP-9、 NT-proBNP、 hs-CRP수평변화정황，병분석기림상의의。방법선택아원우2011년12월지2013년10월접진적102례관심병환자적림상병례자료，포괄AMI （급성심기경사）31례， UAP （불은정심교통）42례， SAP （은정성심교통）29례，병선택래아원적33례건강체검자작위대조조，탐토관심병환자혈MMP-9、 NT-proBNP、 hs-CRP수평변화급의의。결과 AMI조화UAP조환자적혈청MMP-9、 NT-proBNP、 hs-CRP수평균명현고우SAP조화대조조환자적혈청수평（ P＜0.05）， AMI조환자적혈청MMP-9、 NT-proBNP、 hs-CRP수평균명현고우UAP조환자적혈청수평（P＜0.05），이차，수착관맥병변지수적증가，환자적혈청MMP-9、 NT-proBNP、 hs-CRP수평야불단증가，차이유통계학의의（P＜0.05）。결론혈청MMP-9、 NT-proBNP、 hs-CRP수평여관심병환자적병정엄중정도밀절상관，가능재일정정도상예시착관심병환자적병정엄중정도，구유십분중요적림상의의，치득림상삼고。
Objective To investigate the change of MMP-9, NT-proBNP and hs-CRP levels in patients with coronary heart disease and its clinical significance .Methods A total of 102 pa-tients with coronary heart disease who were treated in our hospital from December 2011 to October 2013 were included.There were 31 cases of acute myocardial infarction ( AMI) , 42 cases of unsta-ble angina ( UAP) and 29 cases of stable angina ( SAP) .Thirty-three healthy people were selected as the control group.The levels of MMP-9, NT-proBNP and hs-CRP were detected in patients with coronary heart disease and healthy subjects.Results The serum MMP-9 , NT-proBNP and hs-CRP levels were significantly higher in AMI and UAP groups than in SAP group and control group ( P<0.05 ); the serum MMP-9, NT-proBNP and hs-CRP levels in AMI group were significantly higher than in UAP group ( P<0.05); the serum MMP-9, NT-proBNP and hs-CRP levels were in-creased with the increase of the number of coronary lesions , and the difference was statistically sig-nificant ( P <0.05 ) .Conclusion Serum MMP-9 , NT-proBNP and hs-CRP levels in patients with coronary heart disease are closely related to the severity of coronary artery disease , indicating the severity of coronary lesions.They are of clinical significance and of reference value for physi-cians.