CAJ | 학술논문

目的：探讨儿茶酚氧位甲基转移酶（the catechol-O-methyltransferase， COMT）基因多态性与精神分裂症发病风险及阿立哌唑治疗效应之间的相关性。方法采用病例-对照研究设计，在中国汉族人群中收集78例符合美国精神障碍诊断与统计手册第4版（ DSM-Ⅳ）精神分裂症诊断标准的首发精神分裂症患者，并与65例健康志愿者进行对照。用阳性与阴性症状评定量表（ PANSS ）、临床大体评定量表（ CGI ）评定阿立哌唑治疗的疗效。运用聚合酶链式反应-限制性片段长度多态分析（ PCR-RFLP）方法进行基因分型。结果患者组与正常对照组基因型和等位基因频率分布存在显著性差异（ P均＜0.05）； COMT基因多态性也与精神分裂症患者年龄、病程相关联。经阿立哌唑治疗后，患者精神症状及临床疗效总评分均有明显改善，但其改善程度在3种基因型间比较无明显差异。结论 COMT基因Val158/108 Met多态性与精神分裂症的发病存在关联，但对阿立哌唑的临床疗效可能没有明显影响。
목적：탐토인다분양위갑기전이매（the catechol-O-methyltransferase， COMT）기인다태성여정신분렬증발병풍험급아립고서치료효응지간적상관성。방법채용병례-대조연구설계，재중국한족인군중수집78례부합미국정신장애진단여통계수책제4판（ DSM-Ⅳ）정신분렬증진단표준적수발정신분렬증환자，병여65례건강지원자진행대조。용양성여음성증상평정량표（ PANSS ）、림상대체평정량표（ CGI ）평정아립고서치료적료효。운용취합매련식반응-한제성편단장도다태분석（ PCR-RFLP）방법진행기인분형。결과환자조여정상대조조기인형화등위기인빈솔분포존재현저성차이（ P균＜0.05）； COMT기인다태성야여정신분렬증환자년령、병정상관련。경아립고서치료후，환자정신증상급림상료효총평분균유명현개선，단기개선정도재3충기인형간비교무명현차이。결론 COMT기인Val158/108 Met다태성여정신분렬증적발병존재관련，단대아립고서적림상료효가능몰유명현영향。
Objective To investigate the association between catechol-O-methyltransferase ( COMT) gene polymorphism and onset risk of schizophrenia , efficacy of aripiprazole.Methods A total of 78 Chinese Han schizophrenic patients and 65 healthy subjects were recruited in this stud-y.All the patients were diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders ( DSM-Ⅳ) .The Positive and Negative Syndrome Scale ( PANSS ) and Clinical Global Impression (CGI) were used to evaluate the clinical efficacy of aripiprazole.Polymerase chain reaction (PCR) and restriction fragment length polymorphism ( RFLP ) were employed to detect COMT geno-types.Results The COMT Val158 Met genotype and allele distributions in schizophrenia patients were significantly different from those in health subjects ( P<0.05 ) .The COMT polymorphism was related to age and disease course.In addition , the psychiatric symptoms and the total score of clini-cal efficacy were significantly improved after treatment with aripiprazole , but there was no significant difference in this improvement among the three gene types of COMT ( P>0.05 ) .Conclusions The polymorphism of COMT gene Val 158/Met is correlated with the onset of schizophrenia , but has no effect on the clinical efficacy of aripiprazole.