CAJ | 학술논문

目的：探讨 Ki-67与血管生成拟态(vasculogenic mimicry,VM)在原发性肝细胞癌(hepatocellular carcinoma,HCC)中的表达情况。方法：取87例 HCC 石蜡标本,运用免疫组织化学染色法检测Ki-67的表达,并运用过碘酸雪夫(periodic acid-schiff stain,PAS)和 CD34双染色法进一步标记VM。结果：Ki-67高表达组VM阳性率高于Ki-67低表达组,差别具有统计学意义(P<0.05)。结论：肝细胞癌组织内存在VM表达,且与癌细胞的Ki-67表达密切相关,Ki-67可能参与 VM的形成,是 VM形成的机制之一。
목적：탐토 Ki-67여혈관생성의태(vasculogenic mimicry,VM)재원발성간세포암(hepatocellular carcinoma,HCC)중적표체정황。방법：취87례 HCC 석사표본,운용면역조직화학염색법검측Ki-67적표체,병운용과전산설부(periodic acid-schiff stain,PAS)화 CD34쌍염색법진일보표기VM。결과：Ki-67고표체조VM양성솔고우Ki-67저표체조,차별구유통계학의의(P<0.05)。결론：간세포암조직내존재VM표체,차여암세포적Ki-67표체밀절상관,Ki-67가능삼여 VM적형성,시 VM형성적궤제지일。
Objective:To investigate the expression of vasculogenic mimicry (VM)and Ki-67 in hepatocellular carcinoma (HCC)and their clinical significances.Methods:Take the 87 cases of HCC specimens of paraffin wax,using immunohistochemical staining method to detect the expression of Ki-67,and the use of periodate snow's(periodic acid shchiff-stain,PAS)and CD34 staining method further marked the VM.Results:The VM expression in the group with high Ki-67 expression was significantly higher than that of the group with low Ki-67 expression(P<0.05).Conclusion:The results showed that VM existed in HCC,and it was-associated with Ki-67 expression,which was the possibel mechanism contributing to the formation of VM.