CAJ | 학술논문

目的：探讨阿立哌唑对抗精神病药物所致女性精神分裂症患者高催乳素血症的影响。方法对48例抗精神病药物所致高催乳素血症的女性精神分裂症患者，在维持原用抗精神病药物治疗的基础上联合小剂量阿立哌唑治疗，观察8周。采用阳性与阴性症状量表评定精神症状，副反应量表评定不良反应，同时检测患者血清催乳素水平的变化。结果本组患者治疗后阳性与阴性症状量表及副反应量表评分与治疗前比较差异均无显著性（P＞0．05），而血清催乳素水平较治疗前呈持续性下降，治疗第4周、8周末与治疗前比较差异均有极显著性（ t ＝4．12、6．32，P＜0．01）。结论阿立哌唑能显著改善抗精神病药物所致女性精神分裂症患者的高催乳素血症，疗效显著，不增加不良反应。
목적：탐토아립고서대항정신병약물소치녀성정신분렬증환자고최유소혈증적영향。방법대48례항정신병약물소치고최유소혈증적녀성정신분렬증환자，재유지원용항정신병약물치료적기출상연합소제량아립고서치료，관찰8주。채용양성여음성증상량표평정정신증상，부반응량표평정불량반응，동시검측환자혈청최유소수평적변화。결과본조환자치료후양성여음성증상량표급부반응량표평분여치료전비교차이균무현저성（P＞0．05），이혈청최유소수평교치료전정지속성하강，치료제4주、8주말여치료전비교차이균유겁현저성（ t ＝4．12、6．32，P＜0．01）。결론아립고서능현저개선항정신병약물소치녀성정신분렬증환자적고최유소혈증，료효현저，불증가불량반응。
Objective To explore the effects of aripiprazole on antipsychotic-in-duced hyperprolactinemia (AIH) of female patients with schizophrenia .Methods Forty-eight AIH female schizophrenia patients were plus small-dose aripiprazole on the basis of maintaining original treatment with antipsychotic drugs for 8 weeks .Mental symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) ,changes of patients’ serum prolactin levels detected .Results There were significant differences in the PANSS and TESS scores between post-and pre-treatment (P>0 .05) ,serum prolatin levels lowered continuously and had very significant differences at the end of the 4th and 8th week from pretreatment ( t =4 .12 ,6 .32 ;P<0 .01) .Conclusion Aripiprazole could improve the AIH of female schizophrenia patients notably ,has an evident effect ,and doesn’t increase adverse reactions .