CAJ | 학술논문

目的：探讨抗抑郁剂联合认知疗法治疗门诊抑郁症的临床效果。方法将76例门诊抑郁症患者随机分为两组，均给予常规抗抑郁剂治疗，研究组联合认知疗法，观察10周，随访12个月。采用汉密顿抑郁量表、临床疗效总评量表评定临床疗效，生活质量综合评定问卷评定生活质量，统计患者服药依从性和复发率。结果治疗后两组汉密顿抑郁量表、临床疗效总评量表评分均较治疗前显著下降（P＜0．01），生活质量综合评定问卷总分及躯体健康、心理健康、社会功能维度评分均较治疗前显著升高（ P＜0．05或0．01）。治疗10周末两组总有效率比较差异无显著性（χ2＝0．00，P＞0．05）。随访第12个月研究组服药依从性显著高于对照组，复发率显著低于对照组（χ2＝8．89、10．83，P＜0．01）。结论抗抑郁剂联合认知疗法能快速缓解门诊抑郁症患者的抑郁症状，提高服药依从性及生活质量，降低复发率。
목적：탐토항억욱제연합인지요법치료문진억욱증적림상효과。방법장76례문진억욱증환자수궤분위량조，균급여상규항억욱제치료，연구조연합인지요법，관찰10주，수방12개월。채용한밀돈억욱량표、림상료효총평량표평정림상료효，생활질량종합평정문권평정생활질량，통계환자복약의종성화복발솔。결과치료후량조한밀돈억욱량표、림상료효총평량표평분균교치료전현저하강（P＜0．01），생활질량종합평정문권총분급구체건강、심리건강、사회공능유도평분균교치료전현저승고（ P＜0．05혹0．01）。치료10주말량조총유효솔비교차이무현저성（χ2＝0．00，P＞0．05）。수방제12개월연구조복약의종성현저고우대조조，복발솔현저저우대조조（χ2＝8．89、10．83，P＜0．01）。결론항억욱제연합인지요법능쾌속완해문진억욱증환자적억욱증상，제고복약의종성급생활질량，강저복발솔。
Objective To explore the efficacy of antidepressants combined with cognitive therapy in outpa-tients with depression .Methods Seventy-six outpatients with depression were randomly into two groups , both groups were treated with routine antidepressants ,and research group was plus cognitive therapy for 10 weeks and were traced for 12 months .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and Clinical Global Impression (CGI) and qualities of life with the Generic Quality of Life Inven-tory-74(GQOLI-74) ,patients’ compliance and relapse rate added up .Results After treatment the HAMD and CGI scores of both groups lowered more significantly compared with pretreatment (P<0 .01) ,the to-tal ,somatic and mental health and social function scores of the GQOLI-74 heightened more significantly (P<0 .05 or 0 .01) .At the end of the 10th week total effective rate was no significant group difference (χ2 =0 .00 ,P>0 .05) .At the end of the 12th month follow-up ,drug compliance rate was significantly high-er and relapse rate lower in research than control group (χ2 =8 .89 ,10 .83 ,P<0 .01) .Conclusion Anti-depressants combined with cognitive therapy could quickly relieve depressive symptoms of outpatients with depression ,improve drug compliance and quality of life ,and reduce relapse rate .