实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
7期
68-70
,共3页
支气管肺炎%肌酸激酶同工酶%成本-效果分析%小儿
支氣管肺炎%肌痠激酶同工酶%成本-效果分析%小兒
지기관폐염%기산격매동공매%성본-효과분석%소인
pneumonia%creatine kinase isoenzyme%cost-effectiveness analysis%children
目的：比较分析1，6-二磷酸果糖注射液联合肌苷、1，6-二磷酸果糖注射液及磷酸肌酸3种方案治疗小儿支气管肺炎合并心肌损害的成本-效果。方法将120例支气管肺炎合并心肌损害的患儿按随机数字表法分为果糖联合组、果糖组和磷酸肌酸组3组，每组40例。3组患儿均在接受相同基础治疗的基础上，果糖联合组给予1，6-二磷酸果糖（200 mg·kg-1·d-1）、肌苷注射液（0.2 g·d-1）静脉滴注；果糖组给予1，6-二磷酸果糖注射液（200 mg·kg-1·d-1）、磷酸肌酸组给予磷酸肌酸注射液（0.5 g·d-1）静脉滴注。3组均治疗7 d为1个疗程。观察3组患儿的治愈率，运用药物经济学原理对3种治疗方案进行成本-效果分析。结果果糖联合组、果糖组及磷酸肌酸组的治愈率分别为87.5%、75.0%及92.5%；主药治疗成本分别为187.6元、186.2元、518.7元；主药成本效果比分别为2.14、2.48、5.61。结论1，6-二磷酸果糖联合肌苷为治疗小儿支气管肺炎合并心肌损害的经济有效的治疗方案。
目的：比較分析1，6-二燐痠果糖註射液聯閤肌苷、1，6-二燐痠果糖註射液及燐痠肌痠3種方案治療小兒支氣管肺炎閤併心肌損害的成本-效果。方法將120例支氣管肺炎閤併心肌損害的患兒按隨機數字錶法分為果糖聯閤組、果糖組和燐痠肌痠組3組，每組40例。3組患兒均在接受相同基礎治療的基礎上，果糖聯閤組給予1，6-二燐痠果糖（200 mg·kg-1·d-1）、肌苷註射液（0.2 g·d-1）靜脈滴註；果糖組給予1，6-二燐痠果糖註射液（200 mg·kg-1·d-1）、燐痠肌痠組給予燐痠肌痠註射液（0.5 g·d-1）靜脈滴註。3組均治療7 d為1箇療程。觀察3組患兒的治愈率，運用藥物經濟學原理對3種治療方案進行成本-效果分析。結果果糖聯閤組、果糖組及燐痠肌痠組的治愈率分彆為87.5%、75.0%及92.5%；主藥治療成本分彆為187.6元、186.2元、518.7元；主藥成本效果比分彆為2.14、2.48、5.61。結論1，6-二燐痠果糖聯閤肌苷為治療小兒支氣管肺炎閤併心肌損害的經濟有效的治療方案。
목적：비교분석1，6-이린산과당주사액연합기감、1，6-이린산과당주사액급린산기산3충방안치료소인지기관폐염합병심기손해적성본-효과。방법장120례지기관폐염합병심기손해적환인안수궤수자표법분위과당연합조、과당조화린산기산조3조，매조40례。3조환인균재접수상동기출치료적기출상，과당연합조급여1，6-이린산과당（200 mg·kg-1·d-1）、기감주사액（0.2 g·d-1）정맥적주；과당조급여1，6-이린산과당주사액（200 mg·kg-1·d-1）、린산기산조급여린산기산주사액（0.5 g·d-1）정맥적주。3조균치료7 d위1개료정。관찰3조환인적치유솔，운용약물경제학원리대3충치료방안진행성본-효과분석。결과과당연합조、과당조급린산기산조적치유솔분별위87.5%、75.0%급92.5%；주약치료성본분별위187.6원、186.2원、518.7원；주약성본효과비분별위2.14、2.48、5.61。결론1，6-이린산과당연합기감위치료소인지기관폐염합병심기손해적경제유효적치료방안。
Objective To compare the cost-effectiveness of fructose 1,6-bisphosphate, phospho-creatine and fructose 1,6-bisphosphate combined with inosine for pneumonia complicated by myocardial damage in children. Methods On the basis of basic treatment, 120 patients with bronchopneumonia were randomly treated with fructose 1,6-bisphosphate injection 200 mg·kg-1·d-1 (fructose group, n=40), phosphocreatine injection 0.5 g·d-1(phosphocreatine group, n=40) or fructose 1,6-bisphosphate injection 200 mg·kg-1·d-1 combined with inosine injection 0.5 g·d-1 (combined fructose and inosine group, n=40) for 7 days. The cure rate was observed in the three groups. The cost-effectiveness was analyzed using the principles of pharmacoeconomics. Results The cure rate, main drug costs and main drug cost-effectiveness ratio were, respectively,87.5%,187.6 yuan RMB and 2.14 in combined fructose and inosine group, 75.0%,186.2 yuan RMB and 2.48 in fructose group, and 92.5%,518.7 yuan RMB and 5.61 in phosphocreatine group.Conclusion The combined treatment with fructose 1,6-bisphosphate and inosine is economical and effective for pneumonia complicated by myocardial damage in children.
