CAJ | 학술논문

目的：观察奈达铂和多烯紫杉醇联合放射治疗术后存在预后不良因素的宫颈癌的临床效果。方法将146例术后存在预后不良因素的Ⅰa2-Ⅱa期宫颈癌患者按简单随机方法分为2组，每组73例。研究组采用奈达铂和多烯紫杉醇联合放射治疗，对照组采用顺铂和紫杉醇联合放射治疗。结果研究组和对照组的24个月生存率分别为93.15%（68/73）和84.93%（62/73），局部复发率分别为13.70%（10/73）和19.18%（14/73），远处转移率分别为6.85%（5/73）和10.96%（8/73），2组差异均有统计学意义（均P＜0.05）。结论奈达铂和多烯紫杉醇联合放疗是一个治疗术后存在预后不良因素的宫颈癌患者的安全有效的方案。
목적：관찰내체박화다희자삼순연합방사치료술후존재예후불량인소적궁경암적림상효과。방법장146례술후존재예후불량인소적Ⅰa2-Ⅱa기궁경암환자안간단수궤방법분위2조，매조73례。연구조채용내체박화다희자삼순연합방사치료，대조조채용순박화자삼순연합방사치료。결과연구조화대조조적24개월생존솔분별위93.15%（68/73）화84.93%（62/73），국부복발솔분별위13.70%（10/73）화19.18%（14/73），원처전이솔분별위6.85%（5/73）화10.96%（8/73），2조차이균유통계학의의（균P＜0.05）。결론내체박화다희자삼순연합방료시일개치료술후존재예후불량인소적궁경암환자적안전유효적방안。
Objective To explore the clinical efficacy of combined radiotherapy with nedaplatin and docetaxel for cervical cancer associated with poor prognostic factors. Methods A total of 146Ⅰa2-Ⅱa cervical carcinoma patients with poor prognostic factors were randomized into two groups, with 73 patients in each group. The study group was given combined radiotherapy with nedaplatin and docetaxel. The control group was given combined radiotherapy with cisplatin and paclitaxel. Results The 2-year survival rate, local recurrence rate and distant metastasis rate were, respectively, 93.15%(68/73),13.70%(10/73) and 6.85%(5/73) in study group, and 84.93%(62/73),19.18%(14/73) and 10.96%(8/73) in control group. Differences were significant between the two groups (P<0.05). Conclusion The combined radiotherapy with nedaplatin and docetaxel is safe and effective for cervical cancer associated with poor prognostic factors.