CAJ | 학술논문

为实现表面增强拉曼散射( SERS)信号的快速检测分析，报道了一种简单的利用SiO2包覆对巯基苯甲酸(4MBA)修饰的Ag纳米粒子形成核壳结构纳米颗粒SERS标记物的方法。通过调控溶液中硝酸钠的浓度来控制4MBA-Ag的聚集程度，获得不同的“热点冶效应，然后利用SiO2包覆实现对聚集体的固定。扫描电镜结果证实此种方法非常有效。该体系中SERS的信号强度依赖于4MBA-Ag的聚集程度。该研究结果有助于实现聚集体SERS标记物在生物成像、检测和传感等方面的应用。
위실현표면증강랍만산사( SERS)신호적쾌속검측분석，보도료일충간단적이용SiO2포복대구기분갑산(4MBA)수식적Ag납미입자형성핵각결구납미과립SERS표기물적방법。통과조공용액중초산납적농도래공제4MBA-Ag적취집정도，획득불동적“열점야효응，연후이용SiO2포복실현대취집체적고정。소묘전경결과증실차충방법비상유효。해체계중SERS적신호강도의뢰우4MBA-Ag적취집정도。해연구결과유조우실현취집체SERS표기물재생물성상、검측화전감등방면적응용。
In order to realize the unltrasensitive analysis by using the surface enhanced Raman scat-tering ( SERS) , we presented a simple and reproducible approach to encapsulate the aggregation of 4-mercaptobenzoic acid-modified Ag nanoparticles with silica. In order to obtain “hot spot”, the level of aggregation could be controlled by varying the concentration of NaNO3 , and then the aggre-gation was coated with silica, which was demonstrated with SEM. In conclusion, the SERS signal seriously depended on the level of aggregation. Due to the strong enhancement effect, this technique has the potential in biomedical field.